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European Journal of Pediatrics
Published in: European Journal of Pediatrics 6/2010

01-06-2010 | Original Paper

Smoking and smoking cessation during early pregnancy and its effect on adverse pregnancy outcomes and fetal growth

Authors: Constantine I. Vardavas, Leda Chatzi, Evridiki Patelarou, Estel Plana, Katerina Sarri, Anthony Kafatos, Antonis D. Koutis, Manolis Kogevinas

Published in: European Journal of Pediatrics | Issue 6/2010

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Abstract

Maternal smoking during pregnancy is a significant threat to the fetus. We examined the association between active maternal smoking and smoking cessation during early pregnancy with newborn somatometrics and adverse pregnancy outcomes including preterm delivery, low birth weight, and fetal growth restriction. One thousand four hundred mother–child pairs with extensive questionnaire data were followed up until delivery, within the context of a population-based mother–child cohort study (Rhea study), in Crete, Greece, 2007–2008. Comparing smokers to nonsmokers, the adjusted odds ratio (OR) was 2.8 [95% confidence interval (CI), 1.7, 4.6] for low birth weight and 2.6 (95%CI: 1.6, 4.2) for fetal growth restriction. This corresponded to a 119-g reduction in birth weight, a 0.53-cm reduction in length, and a 0.35-cm reduction in head circumference. Smoking cessation early during pregnancy modified significantly these pregnancy outcomes indicating the necessity for primary smoking prevention.
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Metadata
Title
Smoking and smoking cessation during early pregnancy and its effect on adverse pregnancy outcomes and fetal growth
Authors
Constantine I. Vardavas
Leda Chatzi
Evridiki Patelarou
Estel Plana
Katerina Sarri
Anthony Kafatos
Antonis D. Koutis
Manolis Kogevinas
Publication date
01-06-2010
Publisher
Springer-Verlag
Published in
European Journal of Pediatrics / Issue 6/2010
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-009-1107-9

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