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European Journal of Pediatrics
Published in: European Journal of Pediatrics 4/2010

01-04-2010 | Original Paper

Mycoplasma pneumoniae associated opsoclonus–myoclonus syndrome in three cases

Authors: Benedikt Maria Huber, Susi Strozzi, Maja Steinlin, Christoph Aebi, Simon Fluri

Published in: European Journal of Pediatrics | Issue 4/2010

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Abstract

Opsoclonus–myoclonus syndrome (OMS) is a rare acquired movement disorder occurring in all age groups, predominantly in infants. Although the exact pathogenesis is still undefined, there is strong evidence for a paraneoplastic or parainfectious immune process resulting in central nervous system dysfunction. Mycoplasma pneumoniae has been implicated in a number of immune-mediated neurologic diseases [28]. However, the association of M. pneumoniae and opsoclonus–myoclonus–ataxia syndrome is not well established so far. We present three cases with opsoclonus–myoclonus–ataxia syndrome in adolescents following an infection with M. pneumoniae. Monophasic disease course and full recovery correspond to the favorable prognosis known from parainfectious cases in young adults. This should affect therapeutic consideration. OMS should be added to the spectrum of M. pneumoniae-associated neurologic complications. Nevertheless, neuroblastoma has to be ruled out in all cases of OMS.
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Metadata
Title
Mycoplasma pneumoniae associated opsoclonus–myoclonus syndrome in three cases
Authors
Benedikt Maria Huber
Susi Strozzi
Maja Steinlin
Christoph Aebi
Simon Fluri
Publication date
01-04-2010
Publisher
Springer-Verlag
Published in
European Journal of Pediatrics / Issue 4/2010
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-009-1048-3

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