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01-02-2010 | Original Paper

Programmed death-1 (PD-1) gene polymorphisms lodged in the genetic predispositions of Kawasaki Disease

Authors: Jin-Kyong Chun, Dong Won Kang, Byung Won Yoo, Jeon-Soo Shin, Dong Soo Kim

Published in: European Journal of Pediatrics | Issue 2/2010

Abstract

The purpose of this study is to investigate the association of programmed death-1 gene (PD-1) polymorphisms with genetic predispositions to Kawasaki disease (KD). A total of 73 patients with KD and 100 healthy controls were enrolled from 2007 to 2008. Two single nucleotide polymorphisms of the PD-1 gene, rs41386349 and rs2227981, were analyzed. Higher T allele frequency of rs41386349 was found in the patient group than the control group (p = 0.007, odds ratio (OR) = 1.9, 95% CI = 1.2–2.9). PD-1 rs2227981 polymorphism was not significant in patients with KD comparing with the control group (p = 0.4, OR = 1.2 (0.8–1.9)). Furthermore, no difference of PD-1 polymorphisms between patients with coronary artery dilatation (CAD) and those without CAD was found. Our data support the possibility that PD-1 gene polymorphism may be related with the genetic susceptibility of KD in Korean population.

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Title: Programmed death-1 (PD-1) gene polymorphisms lodged in the genetic predispositions of Kawasaki Disease
Authors: Jin-Kyong Chun
Dong Won Kang
Byung Won Yoo
Jeon-Soo Shin
Dong Soo Kim
Publication date: 01-02-2010
Publisher: Springer-Verlag
Published in: European Journal of Pediatrics / Issue 2/2010
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-009-1002-4

At a glance: The STEP trials

Springer Medicine

Programmed death-1 (PD-1) gene polymorphisms lodged in the genetic predispositions of Kawasaki Disease

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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