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European Journal of Pediatrics

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Open Access 01-07-2009 | Review

Severe hemolysis and methemoglobinemia following fava beans ingestion in glucose-6-phosphatase dehydrogenase deficiency—case report and literature review

Authors: Marijn Schuurman, Dick van Waardenburg, Joost Da Costa, Hendrik Niemarkt, Piet Leroy

Published in: European Journal of Pediatrics | Issue 7/2009

Abstract

Introduction

Reduced concentrations of glucose-6-phospate dehydrogenase (G6PD) render erythrocytes susceptible to hemolysis under conditions of oxidative stress. In favism, the ingestion of fava beans induces an oxidative stress to erythrocytes, leading to acute hemolysis.

Discussion

The simultaneous occurrence of methemoglobinemia has been reported only scarcely, despite the fact that both phenomena are the consequence of a common pathophysiologic mechanism. The presence of methemoglobinemia has important diagnostic and therapeutic consequences. We report a previously healthy boy who presented with combined severe hemolytic anemia and cyanosis due to methemoglobinemia, following the ingestion of fava beans. His condition was complicated by the development of transient acute renal failure. A G6PD-deficiency was diagnosed. We review the literature on the combination of acute hemolysis and methemoglobinemia in favism. Pathophysiologic, diagnostic, and therapeutic aspects of this disorder are discussed.

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Title: Severe hemolysis and methemoglobinemia following fava beans ingestion in glucose-6-phosphatase dehydrogenase deficiency—case report and literature review
Authors: Marijn Schuurman
Dick van Waardenburg
Joost Da Costa
Hendrik Niemarkt
Piet Leroy
Publication date: 01-07-2009
Publisher: Springer-Verlag
Published in: European Journal of Pediatrics / Issue 7/2009
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-009-0952-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Severe hemolysis and methemoglobinemia following fava beans ingestion in glucose-6-phosphatase dehydrogenase deficiency—case report and literature review

Abstract

Introduction

Discussion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Discussion

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