Top

Published in:

01-05-2009 | Short Report

Effectiveness of pamidronate in severe neonatal hypercalcemia caused by subcutaneous fat necrosis: a case report

Authors: G. Lombardi, R. Cabano, L. Bollani, C. Del Forno, M. Stronati

Published in: European Journal of Pediatrics | Issue 5/2009

Abstract

Subcutaneous fat necrosis of the newborn (SCFN) is a panniculitis that develops in fatty areas during the first weeks of life after foetal distress or perinatal complications. Prognosis is generally good with complete regression, but it can be complicated by metabolic abnormalities like hypoglycemia, hypertriglyceridemia, thrombocytopenia, and also potentially life-threatening hypercalcemia. We report a case of severe hypercalcemia complicating SCFN in a newborn who was treated with hyperhydration, furosemide, prednisone, and pamidronate.

Alos N, Eugène D, Fillion M et al (2006) Pamidronate: treatment for severe hypercalcemia in neonatal subcutaneous fat necrosis. Horm Res 65:289–294. doi:10.1159/000092602 PubMedCrossRef

Chen TH, Shewmake SW, Hansen DD et al (1981) Subcutaneous fat necrosis of the newborn. Arch Dermatol 117:36–37. doi:10.1001/archderm.117.1.36 PubMedCrossRef

Cranefield DJ, Odd DE, Harding JE et al (2004) High incidence of nephrocalcinosis in extremely preterm infants treated with dexamethasone. Pediatr Radiol 34:138–142. doi:10.1007/s00247-003-1090-7 PubMedCrossRef

Finne PH, Sanderud J, Aksnes L et al (1998) Hypercalcemia with increased and unregulated 1,25-dihydroxyvitamin D production in a neonate with subcutaneous fat necrosis. J Pediatr 112:792–794. doi:10.1016/S0022-3476(88)80706-6

Fretzin DF, Arias AM (1987) Sclerema neonatorum and subcutaneous fat necrosis of the newborn. Pediatr Dermatol 4:112–122. doi:10.1111/j.1525-1470.1987.tb00764.x PubMedCrossRef

Glorieux FH, Bishop NJ, Plotkin H et al (1998) Cyclic administration of pamidronate in children with severe osteogenesis imperfecta. N Engl J Med 339:947–952. doi:10.1056/NEJM199810013391402 PubMedCrossRef

Hicks MJ, Levy ML, Alexander J et al (1993) Subcutaneous fat necrosis of the newborn and hypercalcemia: case report and review of the literature. Pediatr Dermatol 10:271–276. doi:10.1111/j.1525-1470.1993.tb00375.x PubMedCrossRef

Lewis A, Cowen P, Rodda C et al (1992) Subcutaneous fat necrosis of the newborn complicated by hypercalcemia and thrombocytopenia. Aust J Dermatol 33:141–144. doi:10.1111/j.1440-0960.1992.tb00102.x CrossRef

Norwood-Galloway A, Lebwohl M, Phelps R et al (1987) Subcutaneous fat necrosis of the newborn with hypercalcemia. J Am Acad Dermatol 16:435–439. doi:10.1016/S0190-9622(87)70056-5 PubMedCrossRef

10.

Porter E, McKie A, Beattie TJ et al (2006) Neonatal nephrocalcinosis: long term follow up. Arch Dis Child Fetal Neonatal 91:333–336. doi:10.1136/adc.2006.094755 CrossRef

11.

Requena L (2007) Normal subcutaneous fat, necrosis of adipocytes and classification of the panniculitides. Semin Cutan Med Surg 26:66–70. doi:10.1016/j.sder.2007.02.001 PubMedCrossRef

12.

Sabokar A, Pandey R, Athanasou NA (2003) The effect of particle size and electrical charge on macrophage-osteoclast differentation and bone resorption. J Mater Sci Mater Med 14:731–738. doi:10.1023/A:1025088418878 CrossRef

13.

Saxena AK (1986) Post steroid panniculitis. Australas J Dermatol 27:143. doi:10.1111/j.1440-0960.1986.tb00315.x PubMedCrossRef

14.

Varan B, Gurakan B, Ozbeck N et al (1999) Subcutaneous fat necrosis of the newborn associated with anemia. Pediatr Dermatol 16:381–383. doi:10.1046/j.1525-1470.1999.00100.x PubMedCrossRef

Title: Effectiveness of pamidronate in severe neonatal hypercalcemia caused by subcutaneous fat necrosis: a case report
Authors: G. Lombardi
R. Cabano
L. Bollani
C. Del Forno
M. Stronati
Publication date: 01-05-2009
Publisher: Springer-Verlag
Published in: European Journal of Pediatrics / Issue 5/2009
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-008-0797-8

At a glance: The STEP trials

Springer Medicine

Effectiveness of pamidronate in severe neonatal hypercalcemia caused by subcutaneous fat necrosis: a case report

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 5/2009

Clustering of (auto)immune diseases with early-onset and complicated inflammatory bowel disease

The moulded baby syndrome: incidence and risk factors regarding 1,001 neonates

Plasma endothelin-1 and nitrate levels in Down’s syndrome with complete atrioventricular septal defect-associated pulmonary hypertension: a comparison with non-Down’s syndrome children

Unusually severe phenotype of neonatal primary hyperparathyroidism due to a heterozygous inactivating mutation in the CASR gene

Femoral head epiphysis growth and development among Chinese children aged 0-5 years

Pylephlebitis due to perforated appendicitis in a teenager