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01-09-2007 | Short Report

Adjunctive treatment of disseminated Mycobacterium avium complex infection with interferon alpha-2b in a patient with complete interferon-gamma receptor R1 deficiency

Authors: Carla M. Ward, Harumi Jyonouchi, Sergei V. Kotenko, Sergey V. Smirnov, Rakesh Patel, Helen Aguila, George McSherry, Barry Dashefsky, Steven M. Holland

Published in: European Journal of Pediatrics | Issue 9/2007

Abstract

We report adjunct treatment of (interferon) IFN-α2b (Intron-A) in a patient with complete interferon-γ receptor R1 (IFNGR1) deficiency suffering from disseminated infection with Mycobacterium avium complex (MAC) resistant to multiple anti-mycobacterial agents. A low dose of IFN-α2b (3 × 10⁶ units/m² three times weekly subcutaneously) successfully attenuated progressive hepatosplenomegaly and abdominal/retroperitoneal/pelvic lymphadenopathy, although the patient continued to be mycobacteremic. This is the first report of a complete IFNGR1 deficiency treated with adjuvant IFN-α2b for disseminated MAC infection.

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Title: Adjunctive treatment of disseminated Mycobacterium avium complex infection with interferon alpha-2b in a patient with complete interferon-gamma receptor R1 deficiency
Authors: Carla M. Ward
Harumi Jyonouchi
Sergei V. Kotenko
Sergey V. Smirnov
Rakesh Patel
Helen Aguila
George McSherry
Barry Dashefsky
Steven M. Holland
Publication date: 01-09-2007
Publisher: Springer-Verlag
Published in: European Journal of Pediatrics / Issue 9/2007
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-006-0339-1

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Adjunctive treatment of disseminated Mycobacterium avium complex infection with interferon alpha-2b in a patient with complete interferon-gamma receptor R1 deficiency

Abstract

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Abstract

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