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European Journal of Pediatrics
Published in: European Journal of Pediatrics 12/2005

01-12-2005 | Original Paper

Increased oxidative stress in infants exposed to passive smoking

Authors: Ali Aycicek, Ozcan Erel, Abdurrahim Kocyigit

Published in: European Journal of Pediatrics | Issue 12/2005

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Abstract

The purpose of this study was to assess the effect of passive cigarette smoking on the oxidative and anti-oxidative status of plasma in infants. Eighty-four infants aged 6–28 weeks were divided into two groups: the study group included infants who had been exposed to passive smoking via at least five cigarettes per day for at least the past 6 weeks at home, while the control group included infants who had never been exposed to passive smoking. The antioxidative status of plasma was assessed by the measurement of individual antioxidant components: vitamin C, albumin, bilirubin, uric acid, thiol contents and total antioxidant capacity (TAC 1 and TAC 2). Oxidative status was assessed by the determination of total peroxide levels and the oxidative stress index (OSI 1 and OSI 2). Plasma vitamin C, thiol concentration and TAC 1 and TAC 2 levels were significantly lower, whereas plasma total peroxide levels and OSI 1 and OSI 2 were significantly higher, in passive smoking infants than in the controls (P<0.01). We conclude that passive smoking has a negative impact on numerous parts of the antioxidant defence system in infants, and exposes them to potent oxidative stress.
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Metadata
Title
Increased oxidative stress in infants exposed to passive smoking
Authors
Ali Aycicek
Ozcan Erel
Abdurrahim Kocyigit
Publication date
01-12-2005
Publisher
Springer-Verlag
Published in
European Journal of Pediatrics / Issue 12/2005
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-005-1720-1

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