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European Journal of Pediatrics
Published in: European Journal of Pediatrics 4/2005

01-04-2005 | Short Report

Lactic acidosis caused by sodium nitroprusside in a newborn with congenital heart disease

Authors: Sascha Meyer, Ali Baghai, Nieves-Lucia Sailer, Sven Gottschling

Published in: European Journal of Pediatrics | Issue 4/2005

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Excerpt

Sodium nitroprusside (SNP) is an antihypertensive agent used frequently in the critical care setting. Co-adminstration of the antidote sodium thiosulphate with SNP usually prevents increases in cyanide concentrations during anaesthesia or long-term SNP infusion [2, 3,4]. We report on a newborn with congenital heart disease who developed severe lactic acidosis due to the administration of SNP despite co-medication with sodium thiosulphate. …
Literature
1.
Baskin SI, Porter DW, Rockwood GA, Romano JA, Patel HC, Kiser RC, Cook CM, Ternay AL (1999) In vitro and in vivo comparison of sulphur donors as antidotes to acute cyanide intoxication. J Appl Toxicol 19: 173–183
2.
Curry SC, Carlton MW, Raschke RA (1997) Prevention of fetal and maternal cyanide toxicity from nitroprusside with coinfusion of sodium thiosulfate in gravid ewes. Anesth Analg 84: 1121–1126
3.
Hall VA, Guest JM (1992) Sodium nitroprusside-induced cyanide intoxication and prevention with sodium thiosulfate prophylaxis. Am J Crit Care 1: 19–25
4.
Rindone JP, Sloane EP (1992) Cyanide toxicity from sodium nitroprusside: risks and management. Ann Pharmacother 26: 515–519PubMed
Metadata
Title
Lactic acidosis caused by sodium nitroprusside in a newborn with congenital heart disease
Authors
Sascha Meyer
Ali Baghai
Nieves-Lucia Sailer
Sven Gottschling
Publication date
01-04-2005
Publisher
Springer-Verlag
Published in
European Journal of Pediatrics / Issue 4/2005
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-005-1621-3

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