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01-06-2022 | Magnetic Resonance Imaging | Original Article

In vivo symmetric multi-contrast MRI brain templates and atlas for spontaneously hypertensive rats

Authors: Yingying Yang, Quan Zhang, Jialiang Ren, Qingfeng Zhu, Lixin Wang, Zuojun Geng

Published in: Brain Structure and Function | Issue 5/2022

Abstract

Spontaneously hypertensive rats (SHRs) are a valuable animal model of essential hypertension. The increasing use of SHRs in neuroimaging has generated an urgent demand for a template set that provides a reference for advanced data analysis. Structural T2-weighted magnetic resonance imaging (MRI), diffusion tensor imaging (DTI) and functional MRI scans that were used to build the template set were obtained from 8 SHRs longitudinally scanned in vivo at 10, 24 and 52 weeks of age. These symmetric multi-contrast templates were constructed by iterative registration and averaging. The cortical atlas was derived from the Tohoku atlas, and the subcortical regions were manually delineated based on the templates. A set of SHR brain images named the Hebei Medical University rat brain template set (HRT) comprised 3D symmetric T2WI, raw T2-weighted signal with no added diffusion weighting (B0), fractional anisotropy (FA), mean diffusivity (MD) and blood oxygen level-dependent (BOLD) templates; tissue probability maps (TPMs) of gray matter (GM), white matter (WM) and cerebrospinal fluid (CSF); and a whole-brain atlas with 163 labels. We quantitatively validated the template and characterized the longitudinal changes in brain morphology in different brain tissues as SHRs aged. To our knowledge, the HRT is the first MRI template set for SHRs. We believe that the HRT can serve as a beneficial tool for precise analysis of the SHR brain using structural and functional MRI, which can promote neuroimaging studies on essential hypertension.

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Title: In vivo symmetric multi-contrast MRI brain templates and atlas for spontaneously hypertensive rats
Authors: Yingying Yang
Quan Zhang
Jialiang Ren
Qingfeng Zhu
Lixin Wang
Zuojun Geng
Publication date: 01-06-2022
Publisher: Springer Berlin Heidelberg
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Published in: Brain Structure and Function / Issue 5/2022
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-022-02472-3

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In vivo symmetric multi-contrast MRI brain templates and atlas for spontaneously hypertensive rats

Abstract

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At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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