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Open Access 01-01-2022 | Magnetic Resonance Imaging | Original Article

Manual delineation approaches for direct imaging of the subcortex

Authors: Anneke Alkemade, Martijn J. Mulder, Anne C. Trutti, Birte U. Forstmann

Published in: Brain Structure and Function | Issue 1/2022

Abstract

The growing interest in the human subcortex is accompanied by an increasing number of parcellation procedures to identify deep brain structures in magnetic resonance imaging (MRI) contrasts. Manual procedures continue to form the gold standard for parcellating brain structures and is used for the validation of automated approaches. Performing manual parcellations is a tedious process which requires a systematic and reproducible approach. For this purpose, we created a series of protocols for the anatomical delineation of 21 individual subcortical structures. The intelligibility of the protocols was assessed by calculating Dice similarity coefficients for ten healthy volunteers. In addition, dilated Dice coefficients showed that manual parcellations created using these protocols can provide high-quality training data for automated algorithms. Here, we share the protocols, together with three example MRI datasets and the created manual delineations. The protocols can be applied to create high-quality training data for automated parcellation procedures, as well as for further validation of existing procedures and are shared without restrictions with the research community.

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Title: Manual delineation approaches for direct imaging of the subcortex
Authors: Anneke Alkemade
Martijn J. Mulder
Anne C. Trutti
Birte U. Forstmann
Publication date: 01-01-2022
Publisher: Springer Berlin Heidelberg
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Published in: Brain Structure and Function / Issue 1/2022
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-021-02400-x

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Manual delineation approaches for direct imaging of the subcortex

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