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01-11-2021 | Review

B3Pdb: an archive of blood–brain barrier-penetrating peptides

Authors: Vinod Kumar, Sumeet Patiyal, Rajesh Kumar, Sukriti Sahai, Dilraj Kaur, Anjali Lathwal, Gajendra P. S. Raghava

Published in: Brain Structure and Function | Issue 8/2021

Abstract

The blood–brain barrier poses major hurdles in the treatment of brain-related ailments. Over the past decade, interest in peptides-based therapeutics has thrived a lot because of their higher benefit to risk ratio. However, a complete knowledgebase providing a well-annotated picture of the peptide as a therapeutic molecule to cure brain-related ailments is lacking. We have built up a knowledgebase B3Pdb on blood–brain barrier (BBB)-penetrating peptides in the present study. The B3Pdb holds clinically relevant experimental information on 1225 BBB-penetrating peptides, including mode of delivery, animal model, in vitro/in vivo experiments, chemical modifications, length. Hoping that drug delivery systems can improve central nervous system disorder-related therapeutics. In this regard, B3Pdb is an important resource to support the rational design of therapeutics peptides for CNS-related disorders. The complete ready-to-use and updated database with a user-friendly web interface is available to the scientific community at https://webs.iiitd.edu.in/raghava/b3pdb/.

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Title: B3Pdb: an archive of blood–brain barrier-penetrating peptides
Authors: Vinod Kumar
Sumeet Patiyal
Rajesh Kumar
Sukriti Sahai
Dilraj Kaur
Anjali Lathwal
Gajendra P. S. Raghava
Publication date: 01-11-2021
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 8/2021
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-021-02341-5

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B3Pdb: an archive of blood–brain barrier-penetrating peptides

Abstract

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