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01-07-2021 | Stroke | Original Article

Are visual working memory and episodic memory distinct processes? Insight from stroke patients by lesion-symptom mapping

Authors: Selma Lugtmeijer, Linda Geerligs, Frank Erik de Leeuw, Edward H. F. de Haan, Roy P. C. Kessels, on behalf of The Visual Brain Group

Published in: Brain Structure and Function | Issue 6/2021

Abstract

Working memory and episodic memory are two different processes, although the nature of their interrelationship is debated. As these processes are predominantly studied in isolation, it is unclear whether they crucially rely on different neural substrates. To obtain more insight in this, 81 adults with sub-acute ischemic stroke and 29 elderly controls were assessed on a visual working memory task, followed by a surprise subsequent memory test for the same stimuli. Multivariate, atlas- and track-based lesion-symptom mapping (LSM) analyses were performed to identify anatomical correlates of visual memory. Behavioral results gave moderate evidence for independence between discriminability in working memory and subsequent memory, and strong evidence for a correlation in response bias on the two tasks in stroke patients. LSM analyses suggested there might be independent regions associated with working memory and episodic memory. Lesions in the right arcuate fasciculus were more strongly associated with discriminability in working memory than in subsequent memory, while lesions in the frontal operculum in the right hemisphere were more strongly associated with criterion setting in subsequent memory. These findings support the view that some processes involved in working memory and episodic memory rely on separate mechanisms, while acknowledging that there might also be shared processes.

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Title: Are visual working memory and episodic memory distinct processes? Insight from stroke patients by lesion-symptom mapping
Authors: Selma Lugtmeijer
Linda Geerligs
Frank Erik de Leeuw
Edward H. F. de Haan
Roy P. C. Kessels
on behalf of The Visual Brain Group
Publication date: 01-07-2021
Publisher: Springer Berlin Heidelberg
Keyword: Stroke
Published in: Brain Structure and Function / Issue 6/2021
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-021-02281-0

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Are visual working memory and episodic memory distinct processes? Insight from stroke patients by lesion-symptom mapping

Abstract

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