Top

Published in:

Open Access 01-07-2021 | Magnetic Resonance Imaging | Original Article

Topographic volume-standardization atlas of the human brain

Authors: Kevin Akeret, Christiaan Hendrik Bas van Niftrik, Martina Sebök, Giovanni Muscas, Thomas Visser, Victor E. Staartjes, Federica Marinoni, Carlo Serra, Luca Regli, Niklaus Krayenbühl, Marco Piccirelli, Jorn Fierstra

Published in: Brain Structure and Function | Issue 6/2021

Abstract

Specific anatomical patterns are seen in various diseases affecting the brain. Clinical studies on the topography of pathologies are often limited by the absence of a normalization of the prevalence of pathologies to the relative volume of the affected anatomical structures. A comprehensive reference on the relative volumes of clinically relevant anatomical structures serving for such a normalization, is currently lacking. The analyses are based on anatomical high-resolution three-dimensional T1-weighted magnetic resonance imaging data of 30 healthy Caucasian volunteers, including 14 females (mean age 37.79 years, SD 13.04) and 16 males (mean age 38.31 years, SD 16.91). Semi-automated anatomical segmentation was used, guided by a neuroanatomical parcellation algorithm differentiating 96 structures. Relative volumes were derived by normalizing parenchymal structures to the total individual encephalic volume and ventricular segments to the total individual ventricular volume. The present investigation provides the absolute and relative volumes of 96 anatomical parcellation units of the human encephalon. A larger absolute volume in males than in females is found for almost all parcellation units. While parenchymal structures display a trend towards decreasing volumes with increasing age, a significant inverse effect is seen with the ventricular system. The variances in volumes as well as the effects of gender and age are given for each structure before and after normalization. The provided atlas constitutes an anatomically detailed and comprehensive analysis of the absolute and relative volumes of the human encephalic structures using a clinically oriented parcellation algorithm. It is intended to serve as a reference for volume-standardization in clinical studies on the topographic prevalence of pathologies.

Available only for authorised users

Akeret K, Serra C, Rafi O et al (2019) Anatomical features of primary brain tumors affect seizure risk and semiology. NeuroImage Clin 22:101688. https://doi.org/10.1016/j.nicl.2019.101688CrossRefPubMedPubMedCentral

Akeret K, Staartjes VE, Vasella F et al (2020) Distinct topographic-anatomical patterns in primary and secondary brain tumors and their therapeutic potential. J Neurooncol. https://doi.org/10.1007/s11060-020-03574-wCrossRefPubMedPubMedCentral

Aldusary N, Michels L, Traber GL et al (2019) Lateral geniculate nucleus volumetry at 3T and 7T: four different optimized magnetic-resonance-imaging sequences evaluated against a 7T reference acquisition. Neuroimage. https://doi.org/10.1016/j.neuroimage.2018.09.046CrossRefPubMed

Barton RA, Harvey PH (2000) Mosaic evolution of brain structure in mammals. Nature. https://doi.org/10.1038/35016580CrossRefPubMed

Bede P, Iyer PM, Schuster C et al (2016) The selective anatomical vulnerability of ALS: “disease-defining” and “disease-defying” brain regions. Amyotroph Lateral Scler Front Degener 17:561–570. https://doi.org/10.3109/21678421.2016.1173702CrossRef

Bland JM (2015) An introduction to medical statistics, 4th edn. Oxford University Press, Oxford

Carpenter MB (1972) Atlas of the human brain. Neurology. https://doi.org/10.1212/wnl.22.10.1104CrossRefPubMed

Carrey N, Bernier D, Emms M et al (2012) Smaller volumes of caudate nuclei in prepubertal children with ADHD: impact of age. J Psychiatr Res 46:1066–1072. https://doi.org/10.1016/j.jpsychires.2012.04.025CrossRefPubMed

Chiavaras MM, LeGoualher G, Evans A, Petrides M (2001) Three-dimensional probabilistic atlas of the human orbitofrontal sulci in standardized stereotaxic space. Neuroimage. https://doi.org/10.1006/nimg.2000.0641CrossRefPubMed

Clark DA, Mitra PP, Wang SSH (2001) Scalable architecture in mammalian brains. Nature. https://doi.org/10.1038/35075564CrossRefPubMed

Coffey CE, Wilkinson WE, Parashos L et al (1992) Quantitative cerebral anatomy of the aging human brain: a cross-sectional study using magnetic resonance imaging. Neurology 42:527–527. https://doi.org/10.1212/WNL.42.3.527CrossRefPubMed

Crespo-Facorro B, Kim JJ, Andreasen NC et al (2000) Cerebral cortex: a topographic segmentation method using magnetic resonance imaging. Psychiatry Res Neuroimaging. https://doi.org/10.1016/S0925-4927(00)00072-XCrossRef

Dalmau J, Graus F (2018) Antibody-mediated encephalitis. N Engl J Med 378:840–851. https://doi.org/10.1056/NEJMra1708712CrossRefPubMed

Dekaban AS, Sadowsky D (1978) Changes in brain weights during the span of human life: relation of brain weights to body heights and body weights. Ann Neurol. https://doi.org/10.1002/ana.410040410CrossRefPubMed

DeLisi LE, Hoff AL, Schwartz JE et al (1991) Brain morphology in first-episode schizophrenic-like psychotic patients: a quantitative magnetic resonance imaging study. Biol Psychiatry. https://doi.org/10.1016/0006-3223(91)90044-MCrossRefPubMed

Destrieux C, Fischl B, Dale A, Halgren E (2010) Automatic parcellation of human cortical gyri and sulci using standard anatomical nomenclature. Neuroimage 53:1–15. https://doi.org/10.1016/j.neuroimage.2010.06.010CrossRefPubMedPubMedCentral

Duvernoy HM (2012) The human brain: surface, three-dimensional sectional anatomy with MRI, and blood supply. Springer Sci Bus Media, New York

Duvernoy HM, Cattin F, Risold PY et al (2013) The human hippocampus: functional anatomy, vascularization and serial sections with MRI, 4th edn. Springer, New YorkCrossRef

Feiden W, Feiden U, Gerhard L et al (1985) Rabies encephalitis: immunohistochemical investigations. Clin Neuropathol 4:156–164PubMed

Filipek PA, Kennedy DN, Caviness VS et al (1989) Magnetic resonance imaging–based brain morphometry: development and application to normal subjects. Ann Neurol. https://doi.org/10.1002/ana.410250110CrossRefPubMed

Filipek PA, Richelme C, Kennedy DN, Caviness VS (1994) The young adult human brain: an MRI-based morphometric analysis. Cereb Cortex. https://doi.org/10.1093/cercor/4.4.344CrossRefPubMed

Finlay BL, Darlington RB (1995) Linked regularities in the development and evolution of mammalian brains. Science. https://doi.org/10.1126/science.7777856.CrossRefPubMed

Fischl B, Salat DH, Busa E et al (2002) Whole brain segmentation. Neuron 33:341–355. https://doi.org/10.1016/S0896-6273(02)00569-XCrossRefPubMed

Fischl B, Salat DH, van der Kouwe AJW et al (2004) Sequence-independent segmentation of magnetic resonance images. Neuroimage 23:S69–S84. https://doi.org/10.1016/j.neuroimage.2004.07.016CrossRefPubMed

Good CD, Johnsrude I, Ashburner J et al (2001) Cerebral asymmetry and the effects of sex and handedness on brain structure: a voxel-based morphometric analysis of 465 normal adult human brains. Neuroimage. https://doi.org/10.1006/nimg.2001.0857CrossRefPubMed

Hammers A, Allom R, Koepp MJ et al (2003) Three-dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe. Hum Brain Mapp 19:224–247. https://doi.org/10.1002/hbm.10123CrossRefPubMedPubMedCentral

Harper C, Mina L (1981) A comparison of Australian Caucasian and aboriginal brain weights. Clin Exp Neurol 18:44–51PubMed

Hatazawa J, Ito M, Yamaura H, Matsuzawa T (1982) Sex difference in brain atrophy during aging: a quantitative study with computed tomography. J Am Geriatr Soc. https://doi.org/10.1111/j.1532-5415.1982.tb07092.xCrossRefPubMed

Heckemann RA, Hajnal JV, Aljabar P et al (2006) Automatic anatomical brain MRI segmentation combining label propagation and decision fusion. Neuroimage. https://doi.org/10.1016/j.neuroimage.2006.05.061CrossRefPubMed

Hendrik Bas van Niftrik C, Sebök M, Muscas G et al (2020) Characterizing ipsilateral thalamic diaschisis in symptomatic cerebrovascular steno-occlusive patients. J Cereb Blood Flow Metab 40:563–573. https://doi.org/10.1177/0271678X19830532CrossRefPubMed

Hubbard BM, Anderson JM (1981) A quantitative study of cerebral atrophy in old age and senile dementia. J Neurol Sci. https://doi.org/10.1016/0022-510X(81)90048-4CrossRefPubMed

Kennedy D (1998) Gyri of the human neocortex: an MRI-based analysis of volume and variance. Cereb Cortex 8:372–384. https://doi.org/10.1093/cercor/8.4.372CrossRefPubMed

Kennedy DN, Lange N, Makris N et al (1998) Gyri of the human neocortex: an MRI-based analysis of volume and variance. Cereb Cortex. https://doi.org/10.1093/cercor/8.4.372CrossRefPubMed

Klein A, Mensh B, Ghosh S et al (2005) Mindboggle: automated brain labeling with multiple atlases. BMC Med Imaging. https://doi.org/10.1186/1471-2342-5-7CrossRefPubMedPubMedCentral

Lancaster JL, Cykowski MD, McKay DR et al (2010) Anatomical global spatial normalization. Neuroinformatics 8:171–182. https://doi.org/10.1007/s12021-010-9074-xCrossRefPubMedPubMedCentral

Lorente de Nò R (1934) Studies on the Structure of the Cerebral Cortex II. Continuation of the Study of the Ammonic System. J für Psychol und Neurol 46:113–177

Mai JK, Paxinos G (2012) The human nervous system. Academic press, New York

Mai JK, Paxinos G, Voss T (2008) Atlas of the human brain, 3rd edn. Academic press, New York

Massana G, Serra-Grabulosa JM, Salgado-Pineda P et al (2003) Amygdalar atrophy in panic disorder patients detected by volumetric magnetic resonance imaging. Neuroimage 19:80–90. https://doi.org/10.1016/S1053-8119(03)00036-3CrossRefPubMed

Miller AKH, Alston RL, Corsellis JAN (1980) Variation with age in the volumes of grey and white matter in the cerebral hemispheres of man: measurements with an image analyser. Neuropathol Appl Neurobiol 6:119–132. https://doi.org/10.1111/j.1365-2990.1980.tb00283.xCrossRefPubMed

Nieuwenhuys R, Voogd J, Van Huijzen C (2008) The Human Central Nervous System. Springer, Berlin, Heidelberg, pp 190–680CrossRef

Patel F (1994) 6. Diabetic death bed: post-mortem determination of Hypoglycaemia. Med Sci Law 34:84–87. https://doi.org/10.1177/002580249403400116CrossRefPubMed

R Core Team. (2020). R: A Language and Environment for Statistical Computing. Vienna, Austria. Retrieved from https://www.R-project.org/

Riffkin J, Yücel M, Maruff P et al (2005) A manual and automated MRI study of anterior cingulate and orbito-frontal cortices, and caudate nucleus in obsessive-compulsive disorder: comparison with healthy controls and patients with schizophrenia. Psychiatry Res Neuroimaging 138:99–113. https://doi.org/10.1016/j.pscychresns.2004.11.007CrossRef

Roberts DR, Albrecht MH, Collins HR et al (2017) Effects of spaceflight on astronaut brain structure as indicated on MRI. N Engl J Med 377:1746–1753. https://doi.org/10.1056/NEJMoa1705129CrossRefPubMed

Salamon G, Huang YP, Michotey P et al (1976) Radiologic anatomy of the brain. Springer, BerlinCrossRef

Shattuck DW, Mirza M, Adisetiyo V et al (2008) Construction of a 3D probabilistic atlas of human cortical structures. Neuroimage. https://doi.org/10.1016/j.neuroimage.2007.09.031CrossRefPubMedPubMedCentral

Sheline YI, Gado MH, Price JL (1998) Amygdala core nuclei volumes are decreased in recurrent major depression. NeuroReport 9:2023–2028. https://doi.org/10.1097/00001756-199806220-00021CrossRefPubMed

Shenton ME, Kikinis R, Jolesz FA et al (1992a) Abnormalities of the left temporal lobe and thought disorder in schizophrenia. N Engl J Med 327:604–612. https://doi.org/10.1056/NEJM199208273270905CrossRefPubMed

Shenton ME, Kikinis R, Jolesz FA et al (1992b) Abnormalities of the left temporal lobe and thought disorder in schizophrenia: a quantitative magnetic resonance imaging study. N Engl J Med. https://doi.org/10.1056/NEJM199208273270905CrossRefPubMed

Stephan H, Baron G, Frahm HD, Stephan M (1986) Comparison of the size of brains and brain structures of mammals. Z Mikroskopisch-anatomische Forsch 100(2):189–212

Swaab DF, Hofman MA (1984) Sexual differentiation of the human brain a historical perspective. Prog Brain Res. https://doi.org/10.1016/S0079-6123(08)64447-7CrossRefPubMed

Ten Donkelaar HJ, Broman J, Neumann PE et al (2017) Towards a terminologia neuroanatomica. Clin Anat 30:145–155. https://doi.org/10.1002/ca.22809CrossRefPubMed

Valk J, van der Knaap MS (1992) Toxic encephalopathy. AJNR Am J Neuroradiol 13:747–760PubMed

van Niftrik CHB, Piccirelli M, Bozinov O et al (2018) Impact of baseline CO2 on blood-oxygenation-level-dependent MRI measurements of cerebrovascular reactivity and task-evoked signal activation. Magn Reson Imaging. https://doi.org/10.1016/j.mri.2018.02.002CrossRefPubMed

Vogt C, Vogt O (1922) Erkrankungen der Grosshirnrinde im Lichte der Topistik, Pathoklise und Pathoarchitektonik. J Psychiatr Neurol 28:1–73

Williams AL, Lackey J, Wizov SS et al (2013) Evidence for widespread structural brain changes in glaucoma: a preliminary voxel-based MRI study. Investig Opthalmology vis Sci 54:5880. https://doi.org/10.1167/iovs.13-11776CrossRef

Yasargil MG, Adamson TE, George F et al (1994) Microneurosurgery. CNS Tumours 1:16–29

Zatz LM, Jernigan TL, Ahumada AJ (1982) Changes on computed cranial tomography with aging: intracranial fluid volume. Am J Neuroradiol 3:1PubMed

Title: Topographic volume-standardization atlas of the human brain
Authors: Kevin Akeret
Christiaan Hendrik Bas van Niftrik
Martina Sebök
Giovanni Muscas
Thomas Visser
Victor E. Staartjes
Federica Marinoni
Carlo Serra
Luca Regli
Niklaus Krayenbühl
Marco Piccirelli
Jorn Fierstra
Publication date: 01-07-2021
Publisher: Springer Berlin Heidelberg
Keywords: Magnetic Resonance Imaging
Magnetic Resonance Imaging
Published in: Brain Structure and Function / Issue 6/2021
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-021-02280-1

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Topographic volume-standardization atlas of the human brain

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 6/2021

White matter variability in auditory callosal pathways contributes to variation in the cultural transmission of auditory symbolic systems

Developmental changes of the central sulcus morphology in young children

Correction to: A comparison of diffusion tractography techniques in simulating the generalized Ising model to predict the intrinsic activity of the brain

Age-related differences in negative cognitive empathy but similarities in positive affective empathy

The adhesio interthalamica as a neuroanatomical marker of structural differences in healthy adult population

White matter microstructural changes in short-term learning of a continuous visuomotor sequence