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Brain Structure and Function
Published in: Brain Structure and Function 5/2020

01-06-2020 | Original Article

The association between prenatal endocrine-disrupting chemical exposure and altered resting-state brain fMRI in teenagers

Authors: Jun-Cheng Weng, Chi Ieong Hong, Jeng-Dau Tasi, Chao-Yu Shen, Pen-Hua Su, Shu-Li Wang

Published in: Brain Structure and Function | Issue 5/2020

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Abstract

Many studies have reported that prenatal exposure to endocrine-disrupting chemicals (EDCs) can cause adverse behavioral effects or cognitive dysfunction in children. This study aimed to investigate a relationship of the concentration of prenatal EDCs and brain function in teenagers. We recruited 59 mother–child pairs during the third trimester of pregnancy, and collected and examined the concentration of EDCs, such as heavy metals, phthalates and perfluoroalkyl substances (PFASs), in maternal urine and serum. Resting-state functional magnetic resonance imaging (rs-fMRI) data were collected in teenagers 13–16 years of age, and fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo) were performed to find the association between maternal EDC concentrations and the functional development of the teenage brain. We found a correlation between MBP concentration and activity in the superior frontal gyrus, middle frontal gyrus, middle temporal gyrus and inferior temporal gyrus in the combined group of boys and girls. We also observed a correlation between MBzP concentration and activity in the anterior cingulum gyrus and insula in girls. We found a correlation between lead concentration and activity in the cuneus in the combined group. We also observed a correlation between MeHg concentration and activity in the superior temporal gyrus, caudate nucleus and putamen in the combined group. The PFOS results revealed a negative relationship between activity in the right putamen in boys, girls and the combined group after phthalate or heavy metals were applied as covariates. The PFNA results showed a negative correlation between activity in the left/right putamen and left caudate nucleus in boys, girls and the combined group after phthalate, heavy metals or PFOS were applied as covariates. We examined the correlations between maternal EDC concentrations and brain development and found that the associations with resting-state teenage brains in some circumstances are sex-related.
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Metadata
Title
The association between prenatal endocrine-disrupting chemical exposure and altered resting-state brain fMRI in teenagers
Authors
Jun-Cheng Weng
Chi Ieong Hong
Jeng-Dau Tasi
Chao-Yu Shen
Pen-Hua Su
Shu-Li Wang
Publication date
01-06-2020
Publisher
Springer Berlin Heidelberg
Published in
Brain Structure and Function / Issue 5/2020
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI
https://doi.org/10.1007/s00429-020-02089-4

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Original Article

Central autonomic network functional connectivity: correlation with baroreflex function and cardiovascular variability in older adults

Original Article

The occipital face area is causally involved in identity-related visual-semantic associations

Original Article

Investigating inhibition deficit in schizophrenia using task-modulated brain networks

Original Article

The impact of phantom decoys on the neural processing of valuation

Original Article

Spatiotemporal dynamics of auditory information processing in the insular cortex: an intracranial EEG study using an oddball paradigm

Original Article

Lack of M4 muscarinic receptors in the striatum, thalamus and intergeniculate leaflet alters the biological rhythm of locomotor activity in mice