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01-06-2020 | Original Article

Brain-wide resting-state connectivity regulation by the hippocampus and medial prefrontal cortex is associated with fluid intelligence

Authors: Rui Li, Jing Zhang, Xia Wu, Xiaotong Wen, Buxin Han

Published in: Brain Structure and Function | Issue 5/2020

Abstract

The connectivity hub property of the hippocampus (HIP) and the medial prefrontal cortex (MPFC) is essential for their widespread involvement in cognition; however, the cooperation mechanism between them is far from clear. Herein, using resting-state functional MRI and Gaussian Bayesian network to describe the directed organizing architecture of the HIP–MPFC pathway with regions in the brain, we demonstrated that the HIP and the MPFC have central roles as the driving hub and aggregating hub, respectively. The status of the HIP and the MPFC is dominant in communications between the HIP and the default-mode network, between the HIP and core neurocognitive networks, including the default-mode, frontoparietal, and salience networks, and between brain-wide representative regions, suggesting a strong and robust central position of the two regions in regulating the dynamics of large-scale brain activity. Furthermore, we found that the directed connectivity and flow from the right HIP to the MPFC is significantly linked to fluid intelligence. Together, these results clarify the different roles of the HIP and the MPFC that jointly contribute to network dynamics and cognitive ability from a data-driven insight via the use of the directed connectivity method.

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Title: Brain-wide resting-state connectivity regulation by the hippocampus and medial prefrontal cortex is associated with fluid intelligence
Authors: Rui Li
Jing Zhang
Xia Wu
Xiaotong Wen
Buxin Han
Publication date: 01-06-2020
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 5/2020
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-020-02077-8

At a glance: The STEP trials

Springer Medicine

Brain-wide resting-state connectivity regulation by the hippocampus and medial prefrontal cortex is associated with fluid intelligence

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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