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01-12-2019 | Original Article

Social hierarchy regulates ocular dominance plasticity in adult male mice

Authors: Jenny Balog, Franziska Hintz, Marcel Isstas, Manuel Teichert, Christine Winter, Konrad Lehmann

Published in: Brain Structure and Function | Issue 9/2019

Abstract

We here show that social rank, as assessed by competition for a running wheel, influences ocular dominance plasticity in adult male mice. Dominant animals showed a clear ocular dominance shift after 4 days of MD, whereas their submissive cagemates did not. NMDA receptor activation, reduced GABA inhibition, and serotonin transmission were necessary for this plasticity, but not sufficient to explain the difference between dominant and submissive animals. In contrast, prefrontal dopamine concentration was higher in dominant than submissive mice, and systemic manipulation of dopamine transmission bidirectionally changed ocular dominance plasticity. Thus, we could show that a social hierarchical relationship influences ocular dominance plasticity in the visual cortex via higher-order cortices, most likely the medial prefrontal cortex. Further studies will be needed to elucidate the precise mechanisms by which this regulation takes place.

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Title: Social hierarchy regulates ocular dominance plasticity in adult male mice
Authors: Jenny Balog
Franziska Hintz
Marcel Isstas
Manuel Teichert
Christine Winter
Konrad Lehmann
Publication date: 01-12-2019
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 9/2019
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-019-01959-w

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Social hierarchy regulates ocular dominance plasticity in adult male mice

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