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01-07-2018 | Original Article

When tractography meets tracer injections: a systematic study of trends and variation sources of diffusion-based connectivity

Authors: Dogu Baran Aydogan, Russell Jacobs, Stephanie Dulawa, Summer L. Thompson, Maite Christi Francois, Arthur W. Toga, Hongwei Dong, James A. Knowles, Yonggang Shi

Published in: Brain Structure and Function | Issue 6/2018

Abstract

Tractography is a powerful technique capable of non-invasively reconstructing the structural connections in the brain using diffusion MRI images, but the validation of tractograms is challenging due to lack of ground truth. Owing to recent developments in mapping the mouse brain connectome, high-resolution tracer injection-based axonal projection maps have been created and quickly adopted for the validation of tractography. Previous studies using tracer injections mainly focused on investigating the match in projections and optimal tractography protocols. Being a complicated technique, however, tractography relies on multiple stages of operations and parameters. These factors introduce large variabilities in tractograms, hindering the optimization of protocols and making the interpretation of results difficult. Based on this observation, in contrast to previous studies, in this work we focused on quantifying and ranking the amount of performance variation introduced by these factors. For this purpose, we performed over a million tractography experiments and studied the variability across different subjects, injections, anatomical constraints and tractography parameters. By using N-way ANOVA analysis, we show that all tractography parameters are significant and importantly performance variations with respect to the differences in subjects are comparable to the variations due to tractography parameters, which strongly underlines the importance of fully documenting the tractography protocols in scientific experiments. We also quantitatively show that inclusion of anatomical constraints is the most significant factor for improving tractography performance. Although this critical factor helps reduce false positives, our analysis indicates that anatomy-informed tractography still fails to capture a large portion of axonal projections.

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Title: When tractography meets tracer injections: a systematic study of trends and variation sources of diffusion-based connectivity
Authors: Dogu Baran Aydogan
Russell Jacobs
Stephanie Dulawa
Summer L. Thompson
Maite Christi Francois
Arthur W. Toga
Hongwei Dong
James A. Knowles
Yonggang Shi
Publication date: 01-07-2018
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 6/2018
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-018-1663-8

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When tractography meets tracer injections: a systematic study of trends and variation sources of diffusion-based connectivity

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