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Brain Structure and Function
Published in: Brain Structure and Function 4/2017

Open Access 01-05-2017 | Original Article

Anatomical and molecular characterization of dopamine D1 receptor-expressing neurons of the mouse CA1 dorsal hippocampus

Authors: Emma Puighermanal, Laura Cutando, Jihane Boubaker-Vitre, Eve Honoré, Sophie Longueville, Denis Hervé, Emmanuel Valjent

Published in: Brain Structure and Function | Issue 4/2017

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Abstract

In the hippocampus, a functional role of dopamine D1 receptors (D1R) in synaptic plasticity and memory processes has been suggested by electrophysiological and pharmacological studies. However, comprehension of their function remains elusive due to the lack of knowledge on the precise localization of D1R expression among the diversity of interneuron populations. Using BAC transgenic mice expressing enhanced green fluorescent protein under the control of D1R promoter, we examined the molecular identity of D1R-containing neurons within the CA1 subfield of the dorsal hippocampus. In agreement with previous findings, our analysis revealed that these neurons are essentially GABAergic interneurons, which express several neurochemical markers, including calcium-binding proteins, neuropeptides, and receptors among others. Finally, by using different tools comprising cell type-specific isolation of mRNAs bound to tagged-ribosomes, we provide solid data indicating that D1R is present in a large proportion of interneurons expressing dopamine D2 receptors. Altogether, our study indicates that D1Rs are expressed by different classes of interneurons in all layers examined and not by pyramidal cells, suggesting that CA1 D1R mostly acts via modulation of GABAergic interneurons.
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Metadata
Title
Anatomical and molecular characterization of dopamine D1 receptor-expressing neurons of the mouse CA1 dorsal hippocampus
Authors
Emma Puighermanal
Laura Cutando
Jihane Boubaker-Vitre
Eve Honoré
Sophie Longueville
Denis Hervé
Emmanuel Valjent
Publication date
01-05-2017
Publisher
Springer Berlin Heidelberg
Published in
Brain Structure and Function / Issue 4/2017
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI
https://doi.org/10.1007/s00429-016-1314-x

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