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Brain Structure and Function
Published in: Brain Structure and Function 4/2017

01-05-2017 | Original Article

A diffusion tensor imaging atlas of white matter in tree shrew

Authors: Jian-kun Dai, Shu-xia Wang, Dai Shan, Hai-chen Niu, Hao Lei

Published in: Brain Structure and Function | Issue 4/2017

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Abstract

Tree shrews are small mammals now commonly classified in the order of Scandentia, but have relatively closer affinity to primates than rodents. The species has a high brain-to-body mass ratio and relatively well-differentiated neocortex, and thus has been frequently used in neuroscience research, especially for studies on vision and neurological/psychiatric diseases. The available atlases on tree shrew brain provided only limited information on white matter (WM) anatomy. In this study, diffusion tensor imaging (DTI) was used to study the WM anatomy of tree shrew, with the goal to establish an image-based WM atlas. DTI and T2-weighted anatomical images were acquired in vivo and from fixed brain samples. Deterministic tractography was used for three-dimensional reconstruction and rendering of major WM tracts. Myelin and neurofilaments staining were used to study the microstructural properties of certain WM tracts. Taking into account prior knowledge on tree shrew neuroanatomy, tractography results, and comparisons to the homologous structures in rodents and primates, an image-based WM atlas of tree shrew brain was constructed, which is available to research community upon request.
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Metadata
Title
A diffusion tensor imaging atlas of white matter in tree shrew
Authors
Jian-kun Dai
Shu-xia Wang
Dai Shan
Hai-chen Niu
Hao Lei
Publication date
01-05-2017
Publisher
Springer Berlin Heidelberg
Published in
Brain Structure and Function / Issue 4/2017
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI
https://doi.org/10.1007/s00429-016-1304-z

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