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Open Access 01-03-2017 | Original Article

Human ROBO1 regulates white matter structure in corpus callosum

Authors: Fahimeh Darki, Satu Massinen, Elina Salmela, Hans Matsson, Myriam Peyrard-Janvid, Torkel Klingberg, Juha Kere

Published in: Brain Structure and Function | Issue 2/2017

Abstract

The axon guidance receptor, Robo1, controls the pathfinding of callosal axons in mice. To determine whether the orthologous ROBO1 gene is involved in callosal development also in humans, we studied polymorphisms in the ROBO1 gene and variation in the white matter structure in the corpus callosum using both structural magnetic resonance imaging and diffusion tensor magnetic resonance imaging. We found that five polymorphisms in the regulatory region of ROBO1 were associated with white matter density in the posterior part of the corpus callosum pathways. One of the polymorphisms, rs7631357, was also significantly associated with the probability of connections to the parietal cortical regions. Our results demonstrate that human ROBO1 may be involved in the regulation of the structure and connectivity of posterior part of corpus callosum.

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Title: Human ROBO1 regulates white matter structure in corpus callosum
Authors: Fahimeh Darki
Satu Massinen
Elina Salmela
Hans Matsson
Myriam Peyrard-Janvid
Torkel Klingberg
Juha Kere
Publication date: 01-03-2017
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 2/2017
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-016-1240-y

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Human ROBO1 regulates white matter structure in corpus callosum

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