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01-01-2017 | Original Article

T₁ mapping of the mouse brain following fractionated manganese administration using MP2RAGE

Authors: Luc Driencourt, Carola Jacqueline Romero, Mario Lepore, Florent Eggenschwiler, Olivier Reynaud, Nathalie Just

Published in: Brain Structure and Function | Issue 1/2017

Abstract

With the increasing development of transgenic mouse models of neurodegenerative diseases allowing improved understanding of the underlying mechanisms of these disorders, robust quantitative mapping techniques are also needed in rodents. MP2RAGE has shown great potential for structural imaging in humans at high fields. In the present work, MP2RAGE was successfully implemented at 9.4T and 14.1T. Following fractionated injections of MnCl₂, MP2RAGE images were acquired allowing simultaneous depiction and T₁ mapping of structures in the mouse brain at both fields. In addition, T₁ maps demonstrated significant T₁ shortenings in different structures of the mouse brain (p < 0.0008 at 9.4T, p < 0.000001 at 14.1T). T₁ values recovered to the levels of saline-injected animals 1 month after the last injection except in the pituitary gland. We believe that MP2RAGE represents an important prospective translational tool for further structural MRI.

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Title: T1 mapping of the mouse brain following fractionated manganese administration using MP2RAGE
Authors: Luc Driencourt
Carola Jacqueline Romero
Mario Lepore
Florent Eggenschwiler
Olivier Reynaud
Nathalie Just
Publication date: 01-01-2017
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 1/2017
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-016-1211-3

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T₁ mapping of the mouse brain following fractionated manganese administration using MP2RAGE

Abstract

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Abstract

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