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01-07-2015 | Original Article

Imaging changes associated with cognitive abnormalities in Parkinson’s disease

Authors: Yuko Koshimori, Barbara Segura, Leigh Christopher, Nancy Lobaugh, Sarah Duff-Canning, Romina Mizrahi, Clement Hamani, Anthony E. Lang, Kelly Aminian, Sylvain Houle, Antonio P. Strafella

Published in: Brain Structure and Function | Issue 4/2015

Abstract

The current study investigates both gray and white matter changes in non-demented Parkinson’s disease (PD) patients with varying degrees of mild cognitive deficits and elucidates the relationships between the structural changes and clinical sequelae of PD. Twenty-six PD patients and 15 healthy controls (HCs) were enrolled in the study. Participants underwent T1-weighted and diffusion tensor imaging (DTI) scans. Their cognition was assessed using a neuropsychological battery. Compared with HCs, PD patients showed significant cortical thinning in sensorimotor (left pre- and postcentral gyri) and cognitive (left dorsolateral superior frontal gyrus [DLSFG]) regions. The DLSFG cortical thinning correlated with executive and global cognitive impairment in PD patients. PD patients showed white matter abnormalities as well, primarily in bilateral frontal and temporal regions, which also correlated with executive and global cognitive impairment. These results seem to suggest that both gray and white matter changes in the frontal regions may constitute an early pathological substrate of cognitive impairment of PD providing a sensitive biomarker for brain changes in PD.

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Title: Imaging changes associated with cognitive abnormalities in Parkinson’s disease
Authors: Yuko Koshimori
Barbara Segura
Leigh Christopher
Nancy Lobaugh
Sarah Duff-Canning
Romina Mizrahi
Clement Hamani
Anthony E. Lang
Kelly Aminian
Sylvain Houle
Antonio P. Strafella
Publication date: 01-07-2015
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 4/2015
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-014-0785-x

At a glance: The STEP trials

Springer Medicine

Imaging changes associated with cognitive abnormalities in Parkinson’s disease

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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