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Brain Structure and Function
Published in: Brain Structure and Function 1/2015

01-01-2015 | Original Article

Hippocampal 5-HT1A receptor binding is related to object–location memory in humans

Authors: Yifat Glikmann-Johnston, Michael M. Saling, Jian Chen, Graeme O’Keefe, Sylvia Gong, Henri Tochon-Danguy, Rachel Mulligan, David C. Reutens

Published in: Brain Structure and Function | Issue 1/2015

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Abstract

Animal studies suggest that serotonin, mediated by the 5-HT1A receptor, plays a key role in spatial learning and memory. The role of serotonin in spatial memory in humans has, however, been less well studied. This study examined the relationship between serotonin receptor density in the human brain and spatial learning and memory using the 5-HT1A receptor ligand 18F-4-(2′-methoxyphenyl)-1-[2′-(N-2-pyridinyl)-p-fluorobenzamido]-ethyl-piperazine ([18F] MPPF) and positron emission tomography (PET). Ten neurologically healthy individuals underwent two [18F] MPPF PET scans, one while performing a task which involves processing of high-level spatial information (‘house scan’), and one while performing a task which involves processing of low-level spatial information (‘tunnel scan’). Navigation, recall of arbitrary associations between objects and their spatial location, and ability to draw a plan of the environment were tested following the house scan. 5-HT1A receptor binding did not differ significantly between processing high and low levels of spatial information. Hippocampal asymmetry in [18F] MPPF binding, however, was associated with memory for object–location associations; lower right than left hippocampal binding potential (BPND) was related to better memory performance. We conclude that hippocampal serotonergic function plays a role in a fundamental component of human spatial memory, the ability to recall the location of encountered objects.
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Metadata
Title
Hippocampal 5-HT1A receptor binding is related to object–location memory in humans
Authors
Yifat Glikmann-Johnston
Michael M. Saling
Jian Chen
Graeme O’Keefe
Sylvia Gong
Henri Tochon-Danguy
Rachel Mulligan
David C. Reutens
Publication date
01-01-2015
Publisher
Springer Berlin Heidelberg
Published in
Brain Structure and Function / Issue 1/2015
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI
https://doi.org/10.1007/s00429-013-0675-7

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