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Brain Structure and Function
Published in: Brain Structure and Function 3/2014

01-05-2014 | Original Article

Medullo-ponto-cerebellar white matter degeneration altered brain network organization and cortical morphology in multiple system atrophy

Authors: Chia-Feng Lu, Po-Shan Wang, Yuan-Lin Lao, Hsiu-Mei Wu, Bing-Wen Soong, Yu-Te Wu

Published in: Brain Structure and Function | Issue 3/2014

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Abstract

The cerebellum involves diverse functions from motor coordination to higher cognitive functions. Impairment of the cerebellum can cause ataxia and cerebellar cognitive affective syndrome. Multiple system atrophy of the cerebellar type (MSA-C) is a neurodegenerative disorder with atrophy of medullo-ponto-cerebellar (MPC) white matter (WM). To understand the role of the cerebellum from the perspective of the local structure to the global function in the presence of MPC WM degeneration, we acquired T1-weighted and diffusion tensor images for 17 patients with MSA-C and 19 normal controls. We concurrently used the measures of local morphology, including MPC WM volume and inner surface area, and properties of global network organization based on graph theory for the MSA-C and control groups. The results showed that MPC WM degeneration caused the destruction of cerebello-ponto-cerebral loops, resulting in reduced communication efficiency between regions in the whole-brain network. In addition, the sulcal area of the inner cortical surface in the cerebellum decreased linearly with the MPC WM volume, and the inferoposterior lobe exhibited a steeper atrophy rate than that of vermis regions. We concluded that the integrity of MPC WM is critical in sustaining the local morphology and the global functions of the whole-brain fiber network.
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Metadata
Title
Medullo-ponto-cerebellar white matter degeneration altered brain network organization and cortical morphology in multiple system atrophy
Authors
Chia-Feng Lu
Po-Shan Wang
Yuan-Lin Lao
Hsiu-Mei Wu
Bing-Wen Soong
Yu-Te Wu
Publication date
01-05-2014
Publisher
Springer Berlin Heidelberg
Published in
Brain Structure and Function / Issue 3/2014
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI
https://doi.org/10.1007/s00429-013-0545-3

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