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01-01-2014 | Review

A systematic review of brain frontal lobe parcellation techniques in magnetic resonance imaging

Authors: Simon R. Cox, Karen J. Ferguson, Natalie A. Royle, Susan D. Shenkin, Sarah E. MacPherson, Alasdair M. J. MacLullich, Ian J. Deary, Joanna M. Wardlaw

Published in: Brain Structure and Function | Issue 1/2014

Abstract

Manual volumetric measurement of the brain’s frontal lobe and its subregions from magnetic resonance images (MRIs) is an established method for researching neural correlates of clinical disorders or cognitive functions. However, there is no consensus between methods used to identify relevant boundaries of a given region of interest (ROI) on MRIs, and those used may bear little relation to each other or the underlying structural, functional and connective architecture. This presents challenges for the analysis and synthesis of such results. We therefore performed a systematic literature review to highlight variations in the anatomical boundaries used to measure frontal regions, contextualised by up-to-date evidence from histology, hodology and neuropsychology. We searched EMBASE and MEDLINE for studies in English reporting three-dimensional boundaries for manually delineating the brain’s frontal lobe or sub-regional ROIs from MRIs. Exclusion criteria were: exclusive use of co-ordinate grid systems; insufficient detail to allow method replication; publication in grey literature only. Papers were assessed on quality criteria relating to bias, reproducibility and protocol rationale. There was a large degree of variability in the three-dimensional boundaries of all regions used by the 208 eligible papers. Half of the reports did not justify their rationale for boundary selection, and each paper met on average only three quarters of quality criteria. For the frontal lobe and each subregion (frontal pole, anterior cingulate, dorsolateral, inferior-lateral, and orbitofrontal) we identified reproducible methods for a biologically plausible target ROI. It is hoped that this synthesis will guide the design of future volumetric studies of cerebral structure.

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The data compiled over the course of this review (and the available supplementary material) may provide the basis for further reviews explicitly dealing with the effects of boundary variability on reported results and inconsistencies on a syndrome-specific basis.

These studies too are examinations across a small number of brains and so may not have fully captured population-wide variability.

In addition to the difficulty in identifying the lateral boundary between the IFG and OFC, and the posterior and polar boundaries discussed above.

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Title: A systematic review of brain frontal lobe parcellation techniques in magnetic resonance imaging
Authors: Simon R. Cox
Karen J. Ferguson
Natalie A. Royle
Susan D. Shenkin
Sarah E. MacPherson
Alasdair M. J. MacLullich
Ian J. Deary
Joanna M. Wardlaw
Publication date: 01-01-2014
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 1/2014
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-013-0527-5

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

A systematic review of brain frontal lobe parcellation techniques in magnetic resonance imaging

Abstract

At a glance: The ONWARDS insulin icodec trials

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Abstract

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