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01-11-2013 | Review

Action-verb processing in Parkinson’s disease: new pathways for motor–language coupling

Authors: Juan Felipe Cardona, Oscar Gershanik, Carlos Gelormini-Lezama, Alexander Lee Houck, Sebastian Cardona, Lucila Kargieman, Natalia Trujillo, Analía Arévalo, Lucia Amoruso, Facundo Manes, Agustín Ibáñez

Published in: Brain Structure and Function | Issue 6/2013

Abstract

Recent studies suggest that action-verb processing is particularly affected in early stage Parkinson’s disease (PD), highlighting the potential role of subcortical areas in language processing and in the semantic integration of actions. However, this disorder-related language impairment is frequently unrecognized by clinicians and often remains untreated. Early detection of action-language processing deficits could be critical for diagnosing and developing treatment strategies for PD. In this article, we review how action-verb processing is affected in PD and propose a model in which multiple and parallel frontotemporal circuits between the cortex and the basal ganglia provide the anatomic substrate for supporting action-language processing. We hypothesize that contextual coupling of action-language networks are partially dependent on cortical–subcortical integration, and not only on somatotopic motor cortical organization or in a mirror neuron system. This hypothesis is supported by both experimental and clinical evidence. Then, we identify further research steps that would help to determine the reliability of action-language impairments as an early marker of PD. Finally, theoretical implications for clinical assessment and for models of action-language interaction (action–perception cycle theories, mirror system models of language, and embodied cognition approaches to language) are discussed.

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Title: Action-verb processing in Parkinson’s disease: new pathways for motor–language coupling
Authors: Juan Felipe Cardona
Oscar Gershanik
Carlos Gelormini-Lezama
Alexander Lee Houck
Sebastian Cardona
Lucila Kargieman
Natalia Trujillo
Analía Arévalo
Lucia Amoruso
Facundo Manes
Agustín Ibáñez
Publication date: 01-11-2013
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 6/2013
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-013-0510-1

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Springer Medicine

Action-verb processing in Parkinson’s disease: new pathways for motor–language coupling

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