Top

Published in:

01-01-2014 | Original Article

Cytoarchitecture of mouse and rat cingulate cortex with human homologies

Authors: Brent A. Vogt, George Paxinos

Published in: Brain Structure and Function | Issue 1/2014

Abstract

A gulf exists between cingulate area designations in human neurocytology and those used in rodent brain atlases with a major underpinning of the former being midcingulate cortex (MCC). The present study used images extracted from the Franklin and Paxinos mouse atlas and Paxinos and Watson rat atlas to demonstrate areas comprising MCC and modifications of anterior cingulate (ACC) and retrosplenial cortices. The laminar architecture not available in the atlases is also provided for each cingulate area. Both mouse and rat have a MCC with neurons in all layers that are larger than in ACC and layer Va has particularly prominent neurons and reduced neuron densities. An undifferentiated ACC area 33 lies along the rostral callosal sulcus in rat but not in mouse and area 32 has dorsal and ventral subdivisions with the former having particularly large pyramidal neurons in layer Vb. Both mouse and rat have anterior and posterior divisions of retrosplenial areas 29c and 30, although their cytology is different in rat and mouse. Maps of the rodent cingulate cortices provide for direct comparisons with each region in the human including MCC and it is significant that rodents do not have a posterior cingulate region composed of areas 23 and 31 like the human. It is concluded that rodents and primates, including humans, possess a MCC and this homology along with those in ACC and retrosplenial cortices permit scientists inspired by human considerations to test hypotheses on rodent models of human diseases.

Bacon SJ, Smith AD (1993) A monosynaptic pathway from an identified vasomotor centre in the medial prefrontal cortex to an autonomic area in the thoracic spinal cord. Neuroscience 54:719–728PubMedCrossRef

Brodmann K (1909) Vergleichende Lokalisationslehre der Grosshirnrinde in ihren Prinzipiendargestelltauf Grund des Zellenbaues. Barth, Leipzig

Bush G, Vogt BA, Holmes J, Dale AM, Greve D, Jenike MA, Rosen BR (2002) Dorsal anterior cingulate cortex: a role in reward-based decision-making. Proc Natl Acad Sci 99:523–528PubMedCrossRef

Franklin KBJ, Paxinos G (2007) The mouse brain in stereotaxic coordinates, 3rd edn. Academic Press, San Diego

Gabbott PLA, Warner TA, Jays PRL, Salway P, Busby SJ (2005) Prefrontal cortex in the rat: projections to subcortical autonomic, motor, and limbic centers. J Comp Neurol 492:145–177PubMedCrossRef

Heidbredera CA, Groenewegen HJ (2003) The medial prefrontal cortex in the rat: evidence for a dorso-ventral distinction based upon functional and anatomical characteristics. Neurosci Biobehav Rev 27:555–579CrossRef

Herkenham M (1976) The connections of the nucleus reunions thalami: evidence for the direct thalamo-hippocampal pathway in rat. J Comp Neurol 177:589–610CrossRef

Horikawa K, Kinjo N, Stanley LC, Powell EW (1988) Topographic organization and collateralization of the projections of the anterior and laterodorsal thalamic nuclei to cingulate areas 24 and 29 in the rat. Neurosci Res 6:31–44PubMedCrossRef

Jones BF, Groenewegen HJ, Witter MP (2005) Intrinsic connections of the cingulate cortex in the rat suggest the existence of multiple functionally segregated networks. Neuroscience 133:193–207PubMedCrossRef

Marini G, Pianca L, Tredici G (1996) Thalamocortical projection from the parafascicular nucleus to layer V pyramidal cells in frontal and cingulate areas of the rat. Neurosci Lett 203:81–84PubMedCrossRef

Mayberg HS, Brannan SK, Tekell JL, Silva A, Mahurin RK, McGinnis S, Jerabek PA (2000) Regional metabolic effects of fluoxetine in major depression: Serial changes and relationship to clinical response. Biol Psychiatry 48:830–843PubMedCrossRef

Morecraft RJ, Tanji J (2009) Cingulofrontal interactions and the cingulate motor areas. In: Vogt BA (ed) Cingulate neurobiology and disease. Oxford University Press, Oxford, pp 113-144

Palomero-Gallagher N, Vogt BA, Mayberg HS, Schleicher A, Zilles K (2009) Receptor architecture of human cingulate cortex: evaluation of the four region neurobiological model. Hum Brain Mapp 30:2336–2355PubMedCrossRef

Paperna T, Malach R (1991) Patterns of sensory intermodality relationships in the cerebral cortex of the rat. J Comp Neurol 308:432–456PubMedCrossRef

Paxinos G, Watson C (2007) The rat brain in stereotaxic coordinates, 6th edn. Elsevier Press, New York

Rose JE, Woolsey CN (1948) Structure and relations of limbic cortex and anterior thalamic nuclei in rabbit and cat. J Comp Neurol 89:279–340PubMedCrossRef

Shibata H (1993) Efferent projections from the anterior thalamic nuclei to the cingulate cortex in the rat. J Comp Neurol 330:533–542PubMedCrossRef

Swanson LW (1999) Brain maps: structure of the rat brain, 2nd edn. Elsevier, Amsterdam

Tribollet E, Charpak S, Schmidt A, Dubois-Dauphin M, Dreifuss JJ (1989) Appearance and transient expression of oxytocin receptors in fetal, infant and peripubertal rat brain studied by autoradiography and electrophysiology. J Neurosci 9:1764–1773PubMed

van Groen T, Wyss JM (1995) Projections from the anterodorsal and anteroventral nucleus of the thalamus to the limbic cortex in the rat. J Comp Neurol 358:584–604PubMedCrossRef

van Groen T, Wyss JM (2003) Connections of the retrosplenial granular b cortex in the rat. J Comp Neurol 463:249–263PubMedCrossRef

van Groen T, Vogt BA, Wyss JM (1993) Interconnections between the thalamus and retrosplenial cortex in the rodent brain. In: Neurobiology of cingulate cortex and limbic thalamus. Birkhäuser, Boston, pp 123–150

Vertes RP, Hoover WB (2008) Projections of the paraventricular and paratenial nuclei of the dorsal midline thalamus in the rat. J Comp Neurol 508:212–237PubMedCrossRef

Vogt BA (1993) Structural organization of cingulate cortex: areas, neurons, and somatodendritic transmitter receptors. In: Vogt BA, Gabriel M (eds) Neurobiology of cingulate cortex and limbic thalamus. Birkhäuser Boston, Inc., Boston, pp 19–70

Vogt BA (2009) Regions and subregions of the cingulate cortex. In: Vogt BA (ed) Cingulate neurobiology and disease. Oxford University Press: Oxford, pp 3–30

Vogt BA (2013) Cingulate cortex and pain architecture. In: Paxinos G (ed) The rat nervous system, 4th edn. Elsevier, San Diego (in press)

Vogt BA, Derbyshire SWG (2009) Visceral circuits and cingulate-mediated autonomic functions. In: Vogt BA (ed) Cingulate neurobiology and disease. Oxford University Press, Oxford, pp 219–235

Vogt BA, Miller M (1983) Cortical connections between rat cingulate cortex and visual, motor and postsubicular cortices. J Comp Neurol 216:192–210PubMedCrossRef

Vogt BA, Palomero-Gallagher N (2012) Cingulate cortex. In: Paxinos G, Mai JK (eds) The human nervous system, 3rd edn. Academic Press, London, pp 943–987CrossRef

Vogt BA, Peters A (1981) Form and distribution of neurons in rat cingulate cortex: areas 32, 24 and 29. J Comp Neurol 195:603–625PubMedCrossRef

Vogt BA, Gabriel M, Vogt LJ, Poremba A, Jensen EL, Kubota Y, Kang E (1991) Muscarinic receptor binding increases in anterior thalamus and cingulate cortex during discriminative avoidance learning. J Neurosci 11:1508–1514PubMed

Vogt BA, Nimchinsky EA, Vogt LJ, Hof PR (1995) Human cingulate cortex: surface features, flat maps, and cytoarchitecture. J Comp Neurol 359:490–506PubMedCrossRef

Vogt BA, Berger GR, Derbyshire SWJ (2003) Structural and functional dichotomy of human midcingulate cortex. Eur J Neurosci 18:3134–3144PubMedCentralPubMedCrossRef

Vogt BA, Vogt LJ, Farber NB (2004) Cingulate cortex and models of disease. In: Paxinos G (ed) The rat nervous system, 3rd edn. pp 705–727

Vogt BA, Vogt L, Farber NB, Bush G (2005) Architecture and neurocytology of the monkey cingulate gyrus. J Comp Neurol 485:218–239PubMedCentralPubMedCrossRef

Wager TD, Rilling JK, Smith EE, Sokolik A, Casey KL, Davidson RJ, Kosslyn SM, Rose RM, Cohen JD (2004) Placebo-induced changes in fMRI in the anticipation and experience of pain. Science 303:1162–1167PubMedCrossRef

Wiesendanger R, Wiesendanger M (1982a) The corticopontine system in the rat. I. Mapping of corticopontine neurons. J Comp Neurol 208:215–226PubMedCrossRef

Wiesendanger R, Wiesendanger M (1982b) The corticopontine system in the rat. II. The projection pattern. J Comp Neurol 208:227–238PubMedCrossRef

Title: Cytoarchitecture of mouse and rat cingulate cortex with human homologies
Authors: Brent A. Vogt
George Paxinos
Publication date: 01-01-2014
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 1/2014
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-012-0493-3

At a glance: The STEP trials

Springer Medicine

Cytoarchitecture of mouse and rat cingulate cortex with human homologies

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2014

Musculotopic organization of the motor neurons supplying the mouse hindlimb muscles: a quantitative study using Fluoro-Gold retrograde tracing

Differential regulation of parvalbumin and calretinin interneurons in the prefrontal cortex during adolescence

Neuritin 1 promotes neuronal migration

Comparative dynamics of MAPK/ERK signalling components and immediate early genes in the hippocampus and amygdala following contextual fear conditioning and retrieval

Purkinje cell compartmentalization in the cerebellum of the spontaneous mutant mouse dreher

The functional architecture of S1 during touch observation described with 7 T fMRI