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Brain Structure and Function
Published in: Brain Structure and Function 5-6/2010

Open Access 01-06-2010 | Review

Interoception in anxiety and depression

Authors: Martin P. Paulus, Murray B. Stein

Published in: Brain Structure and Function | Issue 5-6/2010

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Abstract

We review the literature on interoception as it relates to depression and anxiety, with a focus on belief, and alliesthesia. The connection between increased but noisy afferent interoceptive input, self-referential and belief-based states, and top-down modulation of poorly predictive signals is integrated into a neuroanatomical and processing model for depression and anxiety. The advantage of this conceptualization is the ability to specifically examine the interface between basic interoception, self-referential belief-based states, and enhanced top-down modulation to attenuate poor predictability. We conclude that depression and anxiety are not simply interoceptive disorders but are altered interoceptive states as a consequence of noisily amplified self-referential interoceptive predictive belief states.
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Metadata
Title
Interoception in anxiety and depression
Authors
Martin P. Paulus
Murray B. Stein
Publication date
01-06-2010
Publisher
Springer-Verlag
Published in
Brain Structure and Function / Issue 5-6/2010
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI
https://doi.org/10.1007/s00429-010-0258-9

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