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Published in: Brain Structure and Function 6/2004

01-09-2004 | Original Article

Pelvic development in the rabbit embryo: implications in the organogenesis of bladder exstrophy

Authors: S. Beaudoin, P. Barbet, F. Bargy

Published in: Brain Structure and Function | Issue 6/2004

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Abstract

Current theses of the development of bladder exstrophy and its variants rely on defective evolution of the urinary tract and cloacal membrane. They do not account satisfactorily for the clinical features reported in children affected by exstrophy, especially the pelvic bone anomaly. We herein describe the normal development of the pelvic ring in the rabbit embryo and its chronological relationship with the lower urinary tract organogenesis. Our results suggest that these events are intricated and allow us to propose a novel mechanism to explain exstrophies.
Literature
go back to reference Allard S, Adin P, Gouédard L, di Clemente N, Josso N, Orgebin-Crist MC, Picard JY, Xavier F (2000) Molecular mechanisms of hormone-mediated Müllerian duct regression : involvement of β-catenin. Development 127: 3349–3360PubMed Allard S, Adin P, Gouédard L, di Clemente N, Josso N, Orgebin-Crist MC, Picard JY, Xavier F (2000) Molecular mechanisms of hormone-mediated Müllerian duct regression : involvement of β-catenin. Development 127: 3349–3360PubMed
go back to reference Ambrose SS, O’Brien DP (1974) Surgical embryology of the exstrophy-epispadias complex. Surg Clin North Am 54:1379–90PubMed Ambrose SS, O’Brien DP (1974) Surgical embryology of the exstrophy-epispadias complex. Surg Clin North Am 54:1379–90PubMed
go back to reference Beaudoin S, Simon L, Bargy F (1997) Anatomical basis of a common embryological origin for epispadias and bladder or cloacal exstrophies. Surg Radiol Anat 19:11–16PubMed Beaudoin S, Simon L, Bargy F (1997) Anatomical basis of a common embryological origin for epispadias and bladder or cloacal exstrophies. Surg Radiol Anat 19:11–16PubMed
go back to reference Beaudoin S, Barbet P, Bargy F (2003) Developmental stages in the rabbit embryo: guidelines to choose an appropriate experimental model. Fetal Diagn Ther 18:422–427CrossRefPubMed Beaudoin S, Barbet P, Bargy F (2003) Developmental stages in the rabbit embryo: guidelines to choose an appropriate experimental model. Fetal Diagn Ther 18:422–427CrossRefPubMed
go back to reference Benoît J (1982) Le développement embryonnaire et foetal en général. In: Grassé P (ed) Traité de zoologie: anatomie, systématique, biologie, vol. XVI. Masson, Paris, p 297 Benoît J (1982) Le développement embryonnaire et foetal en général. In: Grassé P (ed) Traité de zoologie: anatomie, systématique, biologie, vol. XVI. Masson, Paris, p 297
go back to reference Cohen AR (1991) The Mermaid malformation: Cloacal exstrophy and occult spinal dysraphism. Neurosurg 28:834–843 Cohen AR (1991) The Mermaid malformation: Cloacal exstrophy and occult spinal dysraphism. Neurosurg 28:834–843
go back to reference Dalcq A, Pasteels J (1954) Le développement des vertébrés. De la fécondation à la formation des organes primordiaux. In: Grassé P (ed) Traité de zoologie: anatomie, systématique, biologie, vol. XII. Masson, Paris, pp 39–81 Dalcq A, Pasteels J (1954) Le développement des vertébrés. De la fécondation à la formation des organes primordiaux. In: Grassé P (ed) Traité de zoologie: anatomie, systématique, biologie, vol. XII. Masson, Paris, pp 39–81
go back to reference de Vries PA, Peña A (1982) Posterior sagittal anorectoplasty. J Pediatr Surg 17:638–643PubMed de Vries PA, Peña A (1982) Posterior sagittal anorectoplasty. J Pediatr Surg 17:638–643PubMed
go back to reference Greene WB, Dias LS, Lindseth RE, Torch MA (1991) Musculoskeletal problems in association with cloacal exstrophy. J Bone Joint Surg 73-A(4):551–60 Greene WB, Dias LS, Lindseth RE, Torch MA (1991) Musculoskeletal problems in association with cloacal exstrophy. J Bone Joint Surg 73-A(4):551–60
go back to reference Jeffs RD (1978) Exstrophy and cloacal exstrophy. Urol Clin North Am 5:127–40PubMed Jeffs RD (1978) Exstrophy and cloacal exstrophy. Urol Clin North Am 5:127–40PubMed
go back to reference Johnston TB (1913) Extroversion of the bladder, complicated by the presence of intestinal openings on the surface of the extroverted area. J Anat 48:89–106 Johnston TB (1913) Extroversion of the bladder, complicated by the presence of intestinal openings on the surface of the extroverted area. J Anat 48:89–106
go back to reference Kluth D, Lambrecht W, Reich P (1988) Pathogenesis of hypospadias-more questions than answers. J Pediatr Surg 23:1095–1101PubMed Kluth D, Lambrecht W, Reich P (1988) Pathogenesis of hypospadias-more questions than answers. J Pediatr Surg 23:1095–1101PubMed
go back to reference Kluth D, Hillen M, Lambrecht W (1995) The principles of normal and abnormal hindgut development. J Pediatr Surg 30:1143–1147CrossRefPubMed Kluth D, Hillen M, Lambrecht W (1995) The principles of normal and abnormal hindgut development. J Pediatr Surg 30:1143–1147CrossRefPubMed
go back to reference Lascombes P, Dautel G, Grosdidier G (1989) Anatomical basis of pelvic growth in bladder exstrophy. Surg Radiol Anat 11:85–89PubMed Lascombes P, Dautel G, Grosdidier G (1989) Anatomical basis of pelvic growth in bladder exstrophy. Surg Radiol Anat 11:85–89PubMed
go back to reference Le Douarin NM, Teillet MA, Catala M (1998) Neurulation in amniotes vertebrates : a novel view deduced from the use of quail-chick chimeras. Int J Dev Biol 42:909–916PubMed Le Douarin NM, Teillet MA, Catala M (1998) Neurulation in amniotes vertebrates : a novel view deduced from the use of quail-chick chimeras. Int J Dev Biol 42:909–916PubMed
go back to reference Loder RT, Dayioglu MM ( 1990) Association of congenital vertebral malformations with bldder and cloacal exstrophy. J Pediatr Orthop 10:389–393PubMed Loder RT, Dayioglu MM ( 1990) Association of congenital vertebral malformations with bldder and cloacal exstrophy. J Pediatr Orthop 10:389–393PubMed
go back to reference Lund DP, Hendren DW (1993) Cloacal exstrophy: experience with 20 cases. J Pediatr Surg 28:1360–1369PubMed Lund DP, Hendren DW (1993) Cloacal exstrophy: experience with 20 cases. J Pediatr Surg 28:1360–1369PubMed
go back to reference McAuley JP, Uhthoff HK (1990) The development of the pelvis. In: Uhthoff HK (ed) The embryology of the human locomotor system. Springer-Verlag, Heidelberg, Berlin, New York, pp 107–118 McAuley JP, Uhthoff HK (1990) The development of the pelvis. In: Uhthoff HK (ed) The embryology of the human locomotor system. Springer-Verlag, Heidelberg, Berlin, New York, pp 107–118
go back to reference McGill CW, Polk HC, Canty TG (1978) The clinical basis for a simplified classification of anorectal agenesis. Surg Gyn Obst 146:177–181PubMed McGill CW, Polk HC, Canty TG (1978) The clinical basis for a simplified classification of anorectal agenesis. Surg Gyn Obst 146:177–181PubMed
go back to reference Manzoni GA, Ransley PG, Hurwitz RS (1987) Cloacal exstrophy and cloacal exstrophy variants: a proposed system of classification. J Urol 138:1065–73PubMed Manzoni GA, Ransley PG, Hurwitz RS (1987) Cloacal exstrophy and cloacal exstrophy variants: a proposed system of classification. J Urol 138:1065–73PubMed
go back to reference Marshall VF, Muecke EC (1962) Variations in exstrophy of the bladder. J Urol 88:766–796 Marshall VF, Muecke EC (1962) Variations in exstrophy of the bladder. J Urol 88:766–796
go back to reference Mildenberger H, Kluth D, Dziuba M (1988) Embryology of bladder exstrophy. J Pediatr Surg 23:166–170PubMed Mildenberger H, Kluth D, Dziuba M (1988) Embryology of bladder exstrophy. J Pediatr Surg 23:166–170PubMed
go back to reference Muecke EC (1964) The role of the cloacal membrane in exstrophy: the first successful experimental study. J Urol 92:659–67PubMed Muecke EC (1964) The role of the cloacal membrane in exstrophy: the first successful experimental study. J Urol 92:659–67PubMed
go back to reference Nievelstein RAJ, Van der Werff JFA, Verbeek FJ, Valk J, Vermeij-Keers C (1998) Normal and abnormal embryonic development of the anorectum in human embryos. Teratology 57:70–78CrossRefPubMed Nievelstein RAJ, Van der Werff JFA, Verbeek FJ, Valk J, Vermeij-Keers C (1998) Normal and abnormal embryonic development of the anorectum in human embryos. Teratology 57:70–78CrossRefPubMed
go back to reference Noden DM, de Lahunta A (1985) The embryology of domestic animals. Williams & Wilkins, Baltimore Noden DM, de Lahunta A (1985) The embryology of domestic animals. Williams & Wilkins, Baltimore
go back to reference O’Rahilly R, Müller F (2001) Human embryology and teratology. Wiley-Liss, New York O’Rahilly R, Müller F (2001) Human embryology and teratology. Wiley-Liss, New York
go back to reference Paidas CN, Morreale RF, Holoski KM, Lund RE, Hutchins GM (1999) Septation and differentiation of the embryonic human cloaca. J Pediatr Surg 34:877–884CrossRefPubMed Paidas CN, Morreale RF, Holoski KM, Lund RE, Hutchins GM (1999) Septation and differentiation of the embryonic human cloaca. J Pediatr Surg 34:877–884CrossRefPubMed
go back to reference Patten BM, Barry A (1952) The genesis of exstrophy of the bladder and epispadias. Am J Anat 90:35–53PubMed Patten BM, Barry A (1952) The genesis of exstrophy of the bladder and epispadias. Am J Anat 90:35–53PubMed
go back to reference Richardson MK, Hanken J, Gooneratne ML, Pieau C, Raynaud A, Selwood L, Wright GM (1997) There is no highly conserved embryonic stage in the vertebrates: implications for the current theories of evolution and development. Anat Embryol (Berl) 196:91–106 Richardson MK, Hanken J, Gooneratne ML, Pieau C, Raynaud A, Selwood L, Wright GM (1997) There is no highly conserved embryonic stage in the vertebrates: implications for the current theories of evolution and development. Anat Embryol (Berl) 196:91–106
go back to reference Sheldon CA, Mc Lorie GA, Khoury A, Churchill BM (1990) Duplicate bladder exstrophy: A new variant of clinical and embryological significance. J Urol 144:334–336PubMed Sheldon CA, Mc Lorie GA, Khoury A, Churchill BM (1990) Duplicate bladder exstrophy: A new variant of clinical and embryological significance. J Urol 144:334–336PubMed
go back to reference Solère M (1969) Le cloisonnement du cloaque. In: Atlas d’embryologie humaine. Maloine, Paris, pp 85–107 Solère M (1969) Le cloisonnement du cloaque. In: Atlas d’embryologie humaine. Maloine, Paris, pp 85–107
go back to reference Tourneux F (1888) Sur les premiers développements du cloaque, du tubercule génital et de l’anus chez l’embryon de mouton. J Anat 24:503–517 Tourneux F (1888) Sur les premiers développements du cloaque, du tubercule génital et de l’anus chez l’embryon de mouton. J Anat 24:503–517
go back to reference Van Der Putte SCJ (1986) Normal and abnormal development of the anorectum. J Pediatr Surg 21:434–440PubMed Van Der Putte SCJ (1986) Normal and abnormal development of the anorectum. J Pediatr Surg 21:434–440PubMed
go back to reference Vialleton L (1911) Systèmes et appareils; sequelette. In: Éléments de morphologie des vertébrés. Anatomie et embryologie comparées. Paléontologie et classification. Doin & Fils, Paris, pp 228–233 Vialleton L (1911) Systèmes et appareils; sequelette. In: Éléments de morphologie des vertébrés. Anatomie et embryologie comparées. Paléontologie et classification. Doin & Fils, Paris, pp 228–233
go back to reference Wyburn GM (1937) The development of the infraumbilical portion of the abdominal wall, with remarks on the aetiology of ectopia vesicae. J Anat 71:201–231 Wyburn GM (1937) The development of the infraumbilical portion of the abdominal wall, with remarks on the aetiology of ectopia vesicae. J Anat 71:201–231
Metadata
Title
Pelvic development in the rabbit embryo: implications in the organogenesis of bladder exstrophy
Authors
S. Beaudoin
P. Barbet
F. Bargy
Publication date
01-09-2004
Publisher
Springer-Verlag
Published in
Brain Structure and Function / Issue 6/2004
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI
https://doi.org/10.1007/s00429-004-0414-1

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