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01-04-2022 | Merkel Cell Carcinoma | Original Article

SATB2 is expressed in neuroendocrine carcinoma of the uterine cervix

Authors: Frediano Inzani, Giuseppe Angelico, Angela Santoro, Antonio Travaglino, Luigi Insabato, Antonio Raffone, Damiano Arciuolo, Giulia Scaglione, Nicoletta D’Alessandris, Michele Valente, Angela Carlino, Guido Rindi, Gian Franco Zannoni

Published in: Virchows Archiv | Issue 4/2022

Abstract

Neuroendocrine carcinoma (NEC) of the uterine cervix is less characterized than neuroendocrine neoplasms of other sites such as of the digestive system and the lung. Special AT-rich sequence-binding protein 2 (SATB2) recently emerged as a marker of well-differentiated neuroendocrine tumors of the lower gastrointestinal (GI) tract. Among NECs, SATB2 is more frequently expressed in cutaneous Merkel cell carcinoma than in NEC of other anatomical sites. In our study, we performed an immunohistochemical study of SATB2 in 16 NECs of the uterine cervix, where the expression of these markers is still undefined. SATB2 was expressed in 12/16 cervical NECs (75%), with 7/16 cases (44%) showing SATB2 positivity in ≥ 50% of cells. In 7 cervical NECs associated with a non-neuroendocrine component, the expression of SATB2 was restricted to the neuroendocrine component. SATB2 was positive in all cases that expressed CDX2 (n = 7) and TTF1 (n = 5), with no evident association with p16 and p53. Our study demonstrated that SATB2 is often expressed in NECs of the uterine cervix. This information should be taken into account when assessing the origin of a NEC.

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Title: SATB2 is expressed in neuroendocrine carcinoma of the uterine cervix
Authors: Frediano Inzani
Giuseppe Angelico
Angela Santoro
Antonio Travaglino
Luigi Insabato
Antonio Raffone
Damiano Arciuolo
Giulia Scaglione
Nicoletta D’Alessandris
Michele Valente
Angela Carlino
Guido Rindi
Gian Franco Zannoni
Publication date: 01-04-2022
Publisher: Springer Berlin Heidelberg
Keywords: Merkel Cell Carcinoma
Cervical Cancer
Cervical Cancer
Neuroendocrine Tumor
Published in: Virchows Archiv / Issue 4/2022
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-021-03255-7

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SATB2 is expressed in neuroendocrine carcinoma of the uterine cervix

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