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01-09-2020 | Original Article

Correlation of high LAT1 expression with the prognosis of endometrioid carcinoma of the uterine corpus

Authors: Kimiya Sato, Morikazu Miyamoto, Masashi Takano, Hitoshi Tsuda

Published in: Virchows Archiv | Issue 3/2020

Abstract

The expression of L-type amino acid transporter 1 (LAT1) has been described to play essential roles in cancer cell growth and survival. To determine the significance of LAT1 in the prognosis of endometrial endometrioid carcinoma, we investigated LAT1 expression in 353 endometrioid carcinoma patients by immunohistochemical analysis using tissue microarray. The tumors in which stained tumor cells made up more than 25% of the tumor were graded as high expression. High expression of LAT1 was detected in 29 (8.2%) of patients. The ratio of high LAT1 expression did not significantly differ by age (< 60 vs. ≥ 60), FIGO stage (stage I/II vs. III/IV), histological grade (grade 1 vs. grade 2/3), or lymph node metastasis (positive vs. negative). However, high LAT1 expression in endometrioid carcinoma was associated with a poorer progression-free survival and overall survival, as per the results of the log-rank test (P = 0.0263 and 0.0404, respectively). Cox univariate and multivariate analyses revealed that high LAT1 expression is an independent marker of poor progression-free survival (hazard ratio = 2.598, P = 0.0137), in addition to a higher age (≥ 60 years vs. < 60 years), FIGO stage (stage III/IV vs. I/II), and histological grade (grade 2/3 vs. grade 1). In conclusion, we demonstrate that LAT1 is associated with a poor prognosis of endometrioid carcinoma of the uterine corpus.

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Title: Correlation of high LAT1 expression with the prognosis of endometrioid carcinoma of the uterine corpus
Authors: Kimiya Sato
Morikazu Miyamoto
Masashi Takano
Hitoshi Tsuda
Publication date: 01-09-2020
Publisher: Springer Berlin Heidelberg
Published in: Virchows Archiv / Issue 3/2020
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-020-02781-0

At a glance: The STEP trials

Springer Medicine

Correlation of high LAT1 expression with the prognosis of endometrioid carcinoma of the uterine corpus

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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