Contemporary approaches to soft tissue and bone pathology

Excerpt

Mesenchymal neoplasms are diagnostically challenging, may occur at any anatomic site, and frequently show morphologic and immunophenotypical overlap with other mesenchymal tumors, and with non-mesenchymal lesions. The increasing sophistication of molecular genetic techniques has led to rapid developments in our understanding of the underlying biology of soft tissue and bone tumors, with continued refinements in characterization and biologic stratification, including prediction for entry into specific tailored treatment protocols. This Annual Review issue aims to highlight the current, comprehensive state of the art for various mesenchymal tumor types. Each article in this special issue discusses the biology and line of differentiation taken by these neoplasms, the most salient histomorphologic issues, practical applications of the most up-to-date immunohistochemical and molecular developments, and the increasing role of the soft tissue and/or bone pathologist in directing targeted therapies. …