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Virchows Archiv
Published in: Virchows Archiv 4/2019

01-04-2019 | Review Article

Rational combination of cancer immunotherapy in melanoma

Authors: Mario Mandalà, Piotr Rutkowski

Published in: Virchows Archiv | Issue 4/2019

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Abstract

The recent advances in cancer immunotherapy with unprecedented success in therapy of advanced melanoma represent a turning point in the landscape of melanoma treatment. Given the complexity of activation of immunological system and the physiologic multifactorial homeostatic mechanisms controlling immune responses, combinatorial strategies are eagerly needed in melanoma therapy. Nevertheless, rational selection of immunotherapy combinations should be more biomarker-guided, including not only the cancer immunogram, PD-L1 expression, interferon gene expression signature, mutational burden, and tumor infiltration by CD8+ T cells but also intratumoral T cell exhaustion and microbiota composition. In this review, we summarize the rationale to develop combination treatment strategies in melanoma and discuss biological background that could help to design new combinations in order to improve patients’ outcome.
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Metadata
Title
Rational combination of cancer immunotherapy in melanoma
Authors
Mario Mandalà
Piotr Rutkowski
Publication date
01-04-2019
Publisher
Springer Berlin Heidelberg
Published in
Virchows Archiv / Issue 4/2019
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI
https://doi.org/10.1007/s00428-018-2506-y

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