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Published in: Virchows Archiv 6/2018

01-12-2018 | Review and Perspectives

Recent advances in the histological and molecular classification of endometrial stromal neoplasms

Authors: Joana Ferreira, Ana Félix, Jochen K. Lennerz, Esther Oliva

Published in: Virchows Archiv | Issue 6/2018

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Abstract

This review addresses known features and recent developments in the histological, immunohistochemical, and molecular characterization of endometrial stromal neoplasms. We discuss the spectrum of these tumors, from the benign endometrial stromal nodule to low-grade endometrial stromal sarcoma to uterine undifferentiated sarcomas with a special emphasis on the expanding group of high-grade stromal sarcomas, recently added to the 2014 WHO classification, not only discussing the well-established YWHAE-FAM22 tumors but also two new groups, presenting with BCOR alterations including those with BCOR tandem internal duplications or NTRK fusions. It is likely that this high-grade category of endometrial stromal tumors will expand as increasing molecular data is available.
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Metadata
Title
Recent advances in the histological and molecular classification of endometrial stromal neoplasms
Authors
Joana Ferreira
Ana Félix
Jochen K. Lennerz
Esther Oliva
Publication date
01-12-2018
Publisher
Springer Berlin Heidelberg
Published in
Virchows Archiv / Issue 6/2018
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI
https://doi.org/10.1007/s00428-018-2470-6

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