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Virchows Archiv
Published in: Virchows Archiv 6/2017

01-12-2017 | Brief Report

Mixed papillary-sarcomatoid carcinoma of the penis: report of an aggressive subtype

Authors: Graziele Bovolim, Walter Henriques da Costa, Gustavo Cardoso Guimaraes, Fernando Augusto Soares, Isabela Werneck da Cunha

Published in: Virchows Archiv | Issue 6/2017

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Abstract

Several different histological subtypes of penile carcinoma had been described in the last decades, many with different biological behavior and prognosis. The association of two histological subtypes (mixed tumors) can be observed in one third of the cases. The most common association is of warty and basaloid tumors, two HPV-related carcinomas. Here, we described a mixed papillary-sarcomatoid carcinoma, never reported before. Although it is a clinical aspect of a low-grade verruciform tumor, its prognosis showed it to be very aggressive due to the sarcomatoid component hidden above the papillary component. The two components showed opposite cadherin/vimentin expression pointed to epithelial-mesenchymal transition between them.
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Metadata
Title
Mixed papillary-sarcomatoid carcinoma of the penis: report of an aggressive subtype
Authors
Graziele Bovolim
Walter Henriques da Costa
Gustavo Cardoso Guimaraes
Fernando Augusto Soares
Isabela Werneck da Cunha
Publication date
01-12-2017
Publisher
Springer Berlin Heidelberg
Published in
Virchows Archiv / Issue 6/2017
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI
https://doi.org/10.1007/s00428-017-2191-2

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