Top

Published in:

01-09-2016 | Case Report

Expression of developing neural transcription factors in diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH)

Authors: Antonio García Escudero, Enrique Rodríguez Zarco, Juan Carlos Girón Arjona, María José Ríos Moreno, Katherine Gallardo Rodríguez, Ana Vallejo Benítez, Ricardo González Cámpora

Published in: Virchows Archiv | Issue 3/2016

Abstract

DIPNECH is characterized by neuroendocrine cell hyperplasia, tumorlets, and eventually carcinoid tumors. Although it is regarded by some authors as a preneoplastic condition, this issue is controversial. New pathologic criteria have recently been proposed for the diagnosis of DIPNECH, and a subgroup of carcinoid tumors expressing developing neural transcription factors (DNTFs), with clinicopathologic features similar to those of DIPNECH, has been recognized. This paper reports on the clinical and pathological findings in three cases of DIPNECH and investigates the expression of three DNTFs (TTF1, ASCL1, and POU3F2). All patients were female, with a mean age of 63 years, and all lesions were located in the periphery of the lung. In two cases, typical carcinoids were associated with a spindle-cell component. All neuroendocrine proliferations were DNTF positive. The morphologic (spindle-cell component), phenotypic (DNTF expression), and clinicopathologic (peripheral tumors, female predominance) similarities suggest that DIPNECH may be a preneoplastic lesion for peripheral carcinoids.

Davies SJ, Gosney JR, Hansell DM et al (2007) Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: an under-recognised spectrum of disease. Thorax 62:248–252CrossRefPubMed

Gosney JR, Austin JHM, Jett J et al (2015) Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. In: Travis WD, Brambilla E, Burke AP, Marx A, Nicholson AG (eds) Tumors of the lung, pleura thymus and heart. IARC Press, Lyons, pp 78–79

Aguayo SM, Miller YE, Waldron JA Jr et al (1992) Brief report: idiopathic diffuse hyperplasia of pulmonary neuroendocrine cells and airways disease. New Engl J Med 327:1285–1288CrossRefPubMed

Wirtschafter E, Walts AE, Liu ST, Marchevsky AM (2015) Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia of the lung (DIPNECH): current best evidence. Lung 193:659–667CrossRefPubMed

Travis WD, Colby TV, Corrin B, Shimosato Y, Branbilla E (1999) Histological typing of lung and pleural tumors. In: World Health Organization International Histological Classification of Tumours, vol 3rd. Springer, Berlin

Gorshtein A, Gross DJ, Barak D et al (2012) Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia and the associated lung neuroendocrine tumors: clinical experience with a rare entity. Cancer 118:612–619CrossRefPubMed

Yazawa T (2015) Recent advances in histogenesis research of lung neuroendocrine cancers: evidence obtained from functional analyses of primitive neural/neuroendocrine cell-specific transcription factors. Pathol Int 65:277–285CrossRefPubMed

Nishikawa E, Osada H, Okazaki Y et al (2011) miR-375 is activated by ASH1 and inhibits YAP1 in a lineage-dependent manner in lung cancer. Cancer Res 71:6165–6173CrossRefPubMed

Kashiwagi K, Ishii J, Sakaeda M et al (2012) Differences of molecular expression mechanisms among neural cell adhesion molecule 1, synaptophysin, and chromogranin A in lung cancer cells. Pathol Int 63:232–245CrossRef

10.

Yazawa T, Kamma H, Fujiwara M et al (1999) Lack of class II transactivator causes severe deficiency of HLA-DR expression in small cell lung cancer. J Pathol 187:191–199CrossRefPubMed

11.

Osada H, Tomida S, Yatabe Y et al (2008) Roles of achaete-scute homologue 1 in DKK1 and E-cadherin repression and neuroendocrine differentiation in lung cancer. Cancer Res 68:1647–1655CrossRefPubMed

12.

Lazzaro D, Price M, De Felice M, Di Lauro R (1991) The transcription factor is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the fetal brain. Development 113:1093–1104PubMed

13.

Hosono Y, Yamaguchi T, Mizutani E et al (2012) MYBPH, a transcriptional target of TTF-1, inhibits ROCK1, and reduces cell motility and metastasis. EMBO J 31:481–493CrossRef

14.

Saito RA, Watabe T, Horiguchi K et al (2009) Thyroid transcription factor-1 inhibits transforming growth factor-β-mediated epithelial-to-mesenchymal transition in lung adenocarcinoma cells. Cancer Res 69:2783–2791CrossRefPubMed

15.

Ishii J, Sato H, Yazawa T et al (2014) Class III/IV POU transcription factors expressed in small cell lung cancer cells are involved in proneural/neuroendocrine differentiation. Pathol Int 64:415–422CrossRefPubMed

16.

Endo T, Yazawa T, Shishido-Hara Y et al (2014) Expression of developing neural transcription factors in lung carcinoid tumors. Pathol Int 64:365–374CrossRefPubMed

17.

Folpe AL, Gown AM, Lamps LW et al (1999) Thyroid transcription factor-1: immunohistochemical evaluation in pulmonary neuroendocrine tumors. Mod Pathol 12:5–8PubMed

18.

Andersen B, Rosenfeld MG (2001) POU domain factors in the neuroendocrine system: lessons from developmental biology provide insights into human diseases. Endocr Rev 22:2–35PubMed

19.

Augustyn A, Borromeo M, Wang T et al (2014) ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers. Proc Natl Acad Sci U S A 111:14788–14793CrossRefPubMedPubMedCentral

20.

Sturm N, Rossi G, Lantuejoul S et al (2002) Expression of thyroid transcription factor-1 in the spectrum of neuroendocrine cell lung proliferations with special interest in carcinoids. Hum Pathol 33:175–182CrossRef

21.

Du EZ, Goldstraw P, Zacharias J et al (2004) TTF-1 expression is specific for lung primary in typical and atypical carcinoids: TTF-1-positive carcinoids are predominantly in peripheral location. Hum Pathol 35:825–831CrossRefPubMed

22.

Gosney JR, Williams IJ, Dodson AR, Foster CS (2011) Morphology and antigen expression profile of pulmonary neuroendocrine cells in reactive proliferations and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH). Histopathology 59:751–762CrossRefPubMed

23.

Marchevsky AM, Wirtschafter E, Walts AE (2015) The spectrum of changes in adults with multifocal pulmonary neuroendocrine proliferations: what is the minimum set of pathologic criteria to diagnose DIPNECH? Hum Pathol 46:176–181CrossRef

Title: Expression of developing neural transcription factors in diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH)
Authors: Antonio García Escudero
Enrique Rodríguez Zarco
Juan Carlos Girón Arjona
María José Ríos Moreno
Katherine Gallardo Rodríguez
Ana Vallejo Benítez
Ricardo González Cámpora
Publication date: 01-09-2016
Publisher: Springer Berlin Heidelberg
Published in: Virchows Archiv / Issue 3/2016
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-016-1962-5

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Expression of developing neural transcription factors in diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH)

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 3/2016

Book Review—Diagnostic pathology: soft tissue tumors, 2nd edition

Loss of expression of the SWI/SNF complex is a frequent event in undifferentiated/dedifferentiated urothelial carcinoma of the urinary tract

p16 overexpression in high-grade neuroendocrine carcinomas of the head and neck: potential diagnostic pitfall with HPV-related carcinomas

Micropapillary morphology is an indicator of poor prognosis in patients with urothelial carcinoma treated with transurethral resection and radiochemotherapy

Gastric-type adenocarcinoma in situ of uterine cervix: cytological and histopathological features of two cases

For staining of ALK protein, the novel D5F3 antibody demonstrates superior overall performance in terms of intensity and extent of staining in comparison to the currently used ALK1 antibody