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01-04-2016 | Original Article

A significant subgroup of resectable gallbladder cancer patients has an HER2 positive status

Authors: Hiroshi Yoshida, Kazuaki Shimada, Tomoo Kosuge, Nobuyoshi Hiraoka

Published in: Virchows Archiv | Issue 4/2016

Abstract

Gallbladder cancer (GBC) has a poor prognosis, and new targeted therapeutic options are needed. We investigated the human epidermal growth factor receptor 2 (HER2) status and its clinicopathological significance in a large cohort of GBC patients. We assessed HER2 expression in a consecutive series of 211 GBC cases by immunohistochemistry (IHC), paying particular attention to intratumoral heterogeneity. HER2 gene amplification was analyzed by dual-color fluorescence in situ hybridization (FISH). An HER2 positive status was called when the IHC score was 3+ or when the IHC score was 2+, and FISH was positive. Correlations were analyzed between HER2 status and clinicopathological parameters including survival. The HER2 IHC score was 0 in 144 (68.2 %), 1+ in 28 (13.3 %), 2+ in 14 (6.6 %), and 3+ in 25 cases (11.8 %). In 20/39 (51 %) of the IHC 2+ and 3+ cases, the staining pattern was heterogeneous. In HER2 IHC score 2+ and 3+ cases, HER2 FISH was positive in 83 % (10/12) and 96 % (24/25), respectively. Altogether, 35/211 cases (16.6 %) were HER2 positive. There was no significant association between HER2 status and clinicopathological variables or survival. We identified a significant subgroup of HER2-positive GBC cases, for whom a clinical trial with anti-HER2 therapy might be considered.

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Title: A significant subgroup of resectable gallbladder cancer patients has an HER2 positive status
Authors: Hiroshi Yoshida
Kazuaki Shimada
Tomoo Kosuge
Nobuyoshi Hiraoka
Publication date: 01-04-2016
Publisher: Springer Berlin Heidelberg
Published in: Virchows Archiv / Issue 4/2016
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-015-1898-1

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

A significant subgroup of resectable gallbladder cancer patients has an HER2 positive status

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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