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01-11-2010 | Original Article

An additional long-term mechanism of NF-κB regulation after cytokine treatment in a human hepatoma cell line

Author: Patricia Kohlhof

Published in: Virchows Archiv | Issue 5/2010

Abstract

The eukaryotic transcription factor nuclear factor-κB (NF-κB) is mainly involved in the regulation of immune response and inflammation. A prolonged activation of NF-κB has been reported in context with chronic diseases. What leads to a prolongation of NF-κB activity is not well understood. Here, an increase in total intracellular NF-κB protein and mRNA levels as well as a temporary colocalization of NF-κB with proteasomes in human hepatocytes after treatment with TNF-α or IL-1β is reported. This indicates that beside an instantaneous activation of NF-κB and partly autoregulated inactivation by breakdown and synthesis of the inhibitors of NF-κB (IκBs), there are also mechanisms for a long-term regulation by de novo-synthesis and degradation of NF-κB protein.

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Title: An additional long-term mechanism of NF-κB regulation after cytokine treatment in a human hepatoma cell line
Author: Patricia Kohlhof
Publication date: 01-11-2010
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 5/2010
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-010-0970-0

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An additional long-term mechanism of NF-κB regulation after cytokine treatment in a human hepatoma cell line

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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