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Virchows Archiv
Published in: Virchows Archiv 4/2007

01-10-2007 | Letter to the Editor

The neonatal Fc receptor (FcRn) expression in the human skin

Authors: Petru Cianga, Corina Cianga, Petru Plamadeala, Daciana Branisteanu, Eugen Carasevici

Published in: Virchows Archiv | Issue 4/2007

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Excerpt

The neonatal Fc receptor, FcRn, has a wide expression within the human body, including adult cells; however, it is not ubiquitously expressed (reviewed in [2]). The receptor is involved both in IgG transcytosis as well as recycling, being able to bind both free and antigen complexed IgG molecules (reviewed in [4]). …
Literature
1.
Cauza K, Hinterhuber G, Dingelmaier-Hovorka R, Brugger K, Klosner G, Horvat R, Wolff K, Foedinger D (2005) Expression of FcRn, the MHC class I-related receptor for IgG, in human keratinocytes. J Invest Dermatol 124:132–139PubMedCrossRef
2.
Cianga P, Cianga C, Cozma L, Ward ES, Carasevici E (2003) The MHC class I related Fc receptor, FcRn, is expressed in the epithelial cells of the human mammary gland. Hum Immunol 64:1152–1159PubMedCrossRef
3.
Cochran AJ, Lu HF, Li PX, Saxton R, Wen DR (1993) S-100 protein remains a practical marker for melanocytic and other tumours. Melanoma Res 3:325–330PubMedCrossRef
4.
Ghetie V, Ward ES (2000) Multiple roles for the major histocompatibility complex class I-related receptor FcRn. Annu Rev Immunol 18:739–766PubMedCrossRef
5.
Zhu X, Meng G, Dickinson BL, Li X, Mizoguchi E, Miao L, Wang Y, Robert C, Wu B, Smith PD, Lencer WI, Blumberg RS (2001) MHC Class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages and dendritic cells. J Immunol 166:3266–3276PubMed
Metadata
Title
The neonatal Fc receptor (FcRn) expression in the human skin
Authors
Petru Cianga
Corina Cianga
Petru Plamadeala
Daciana Branisteanu
Eugen Carasevici
Publication date
01-10-2007
Publisher
Springer-Verlag
Published in
Virchows Archiv / Issue 4/2007
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI
https://doi.org/10.1007/s00428-007-0467-7

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