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01-06-2007 | Original Article

Acute interstitial nephritis of HIV-positive patients under atazanavir and tenofovir therapy in a retrospective analysis of kidney biopsies

Authors: Simone Schmid, Milos Opravil, Michael Moddel, Milo Huber, Rahel Pfammatter, Gerald Keusch, Patrice Ambuhl, Rudolf P. Wuthrich, Holger Moch, Zsuzsanna Varga

Published in: Virchows Archiv | Issue 6/2007

Abstract

We performed a retrospective analysis on kidney biopsies of 30 human immunodeficiency virus (HIV)-positive patients. Twenty-two of them received highly active antiretroviral therapy (HAART). Tenofovir containing HAART together with atazanavir, a new protease inhibitor, was administered to three patients. All of them developed acute renal failure. The kidney biopsies of these patients showed an acute interstitial nephritis or a chronic interstitial nephritis with an acute component. Withdrawal of atazanavir and tenofovir resulted in recovery of renal function in all three patients. Acute interstitial nephritis was observed only in 1 of 19 patients without atazanavir or tenofovir treatment. We conclude that acute interstitial nephritis and consecutive acute renal failure is a relevant side effect of atazanavir and tenofovir therapy in HIV-positive patients.

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Title: Acute interstitial nephritis of HIV-positive patients under atazanavir and tenofovir therapy in a retrospective analysis of kidney biopsies
Authors: Simone Schmid
Milos Opravil
Michael Moddel
Milo Huber
Rahel Pfammatter
Gerald Keusch
Patrice Ambuhl
Rudolf P. Wuthrich
Holger Moch
Zsuzsanna Varga
Publication date: 01-06-2007
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 6/2007
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-007-0418-3

At a glance: The STEP trials

Springer Medicine

Acute interstitial nephritis of HIV-positive patients under atazanavir and tenofovir therapy in a retrospective analysis of kidney biopsies

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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