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01-02-2007 | Original Article

KiSS-1 overexpression as an independent prognostic marker in hepatocellular carcinoma: an immunohistochemical study

Authors: Katharina Schmid, Xiaowei Wang, Andrea Haitel, Wolfgang Sieghart, Markus Peck-Radosavljevic, Martin Bodingbauer, Susanne Rasoul-Rockenschaub, Fritz Wrba

Published in: Virchows Archiv | Issue 2/2007

Abstract

The KiSS-1 gene has been reported to play an important role as a metastasis suppressor gene in various human malignancies. However, there is little information about its possible role in hepatocellular carcinoma (HCC). In this study, we evaluated the prognostic significance of the expression of KiSS-1 and its receptor AXOR12 in 142 HCC tissue specimens by immunohistochemistry. By using a cutoff level of 50%, immunoreactivity of KiSS-1 and AXOR12 was found in 6 (4%) and 11 (8%) HCCs. The expression of KiSS-1 and AXOR12 in HCC correlated with each other (r = 0.42, p < 0.0001) and with the expression in corresponding, surrounding liver tissue (both r = 0.35, p < 0.0001). Positive AXOR12 immunoreactivity in HCC correlated with advanced pT-stage of tumors and low tumor grading (r = 0.18, p = 0.032; r = −0.18, p = 0.029). High KiSS-1 expression in HCC had a statistically significant influence on diminished disease-free and overall survival in uni- (p = 0.006 and p = 0.002) and multivariate analysis (r = 2.874, p = 0.027 and r = 2.913, p = 0.026). In this study, we report for the first time that elevated KiSS-1 expression level in HCC correlates with worsened clinical outcome, as an independent prognostic marker for the aggressiveness of HCC.

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Title: KiSS-1 overexpression as an independent prognostic marker in hepatocellular carcinoma: an immunohistochemical study
Authors: Katharina Schmid
Xiaowei Wang
Andrea Haitel
Wolfgang Sieghart
Markus Peck-Radosavljevic
Martin Bodingbauer
Susanne Rasoul-Rockenschaub
Fritz Wrba
Publication date: 01-02-2007
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 2/2007
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-006-0352-9

At a glance: The STEP trials

Springer Medicine

KiSS-1 overexpression as an independent prognostic marker in hepatocellular carcinoma: an immunohistochemical study

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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