Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Virchows Archiv
Published in: Virchows Archiv 4/2006

01-10-2006 | Case Report

Primary mantle cell lymphoma of the conjunctiva: a case report

Authors: Miltiadis Aspiotis, Spiridon Gorezis, Ioannis Asproudis, Elena Tsanou, Evangelos Papadiotis, Sevasti Kamina, Niki J. Agnantis, Maria Bai

Published in: Virchows Archiv | Issue 4/2006

Login to get access

Abstract

Primary non-Hodgkin’s lymphomas of the conjunctiva are uncommon. They are almost exclusively extranodal marginal zone B-cell lymphomas/mucosa-associated lymphoid tissue lymphomas. In this study, we report an extremely rare case of conjunctival mantle cell lymphoma in a 78-year-old man, presenting as a unilateral epibulbar mass.
Literature
1.
Aisenberg AC (1991) Extranodal lymphoma: presentation, natural history and special treatment considerations. In: Aisenberg AC (ed) Malignant lymphoma. Lea and Fabiger, Philadelphia, pp 235–310
2.
Akpek EK, Polcharoen W, Ferry JA, Foster CS (1999) Conjunctival lymphoma masquerading as chronic conjunctivitis. Ophthalmology 106:757–760PubMedCrossRef
3.
Auw-Haedrich C, Coupland SE, Kapp A, Schmitt-Graff A, Buchen R, Witschel H (2001) Long term outcome of ocular adnexal lymphoma subtyped according to the REAL classification. Revised European and American Lymphoma. Br J Ophthalmol 85:63–69PubMedCrossRef
4.
Cahill M, Barnes C, Moriarty P, Daly P, Kennedy S (1999) Ocular adnexal lymphoma-comparison of MALT lymphoma with other histological types. Br J Ophthalmol 83:742–747PubMedCrossRef
5.
Calvo R, Ribera JM, Vaquero M, Garcia O, Moreno I, Feliu E (1997) Low-grade, malt-type, primary B-cell lymphoma of the conjunctiva. Leuk Lymphoma 28:203–207PubMed
6.
Charlotte F, Doghmi K, Cassoux N, Ye H, Du MQ, Kujas M, Lesot A, Mansour G, Lehoang P, Vignot N, Capron F, Leblond V (2006) Ocular adnexal marginal zone B cell lymphoma: a clinical and pathologic study of 23 cases. Virchows Arch 448:506–516PubMedCrossRef
7.
Cheuk W, Wong KO, Wong CS, Chan JK (2004) Consistent immunostaining for cyclin D1 can be achieved on a routine basis using a newly available rabbit monoclonal antibody. Am J Surg Pathol 28:801–807PubMedCrossRef
8.
Cho EY, Han JJ, Ree HJ, Ko YH, Kang YK, Ahn HS, Ahn SD, Park CJ, Huh J (2003) Clinicopathologic analysis of ocular adnexal lymphomas: extranodal marginal zone b-cell lymphoma constitutes the vast majority of ocular lymphomas among Koreans and affects younger patients. Am J Hematol 73:87–96PubMedCrossRef
9.
Coupland SE, Krause L, Delecluse HJ, Anagnostopoulos I, Foss HD, Hummel M, Bornfeld N, Lee WR, Stein H (1998) Lymphoproliferative lesions of the ocular adnexa. Analysis of 112 cases. Ophthalmology 105:1430–1441PubMedCrossRef
10.
Ellis JH, Banks PM, Campbell RJ, Liesegang TJ (1985) Lymphoid tumors of the ocular adnexa. Clinical correlation with the working formulation classification and immunoperoxidase staining of paraffin sections. Ophthalmology 92:1311–1324PubMed
11.
Freeman C, Berg JW, Cutler SJ (1972) Occurrence and prognosis of extranodal lymphomas. Cancer 29:252–260PubMedCrossRef
12.
Grossniklaus HE, Green WR, Luckenbach M, Chan CC (1987) Conjunctival lesions in adults. A clinical and histopathologic review. Cornea 6:78–116 (Review)PubMed
13.
Isaacson PG, Norton AJ (1994) Lymphomas of the ocular adnexa and eye. In: Nuttall J, Daniels L, Singleton P (eds) Extranodal lymphomas. Churchill Livingstone, Edinburgh, pp 117–129
14.
Jenkins C, Rose GE, Bunce C, Wright JE, Cree IA, Plowman N, Lightman S, Moseley I, Norton A (2000) Histological features of ocular adnexal lymphoma (REAL classification) and their association with patient morbidity and survival. Br J Ophthalmol 84:907–913PubMedCrossRef
15.
Knowles DM, Jakobiec FA, McNally L, Burke JS (1990) Lymphoid hyperplasia and malignant lymphoma occurring in the ocular adnexa (orbit, conjunctiva, and eyelids): a prospective multiparametric analysis of 108 cases during 1977 to 1987. Hum Pathol 21:959–973PubMedCrossRef
16.
Kurz-Levin MM, Flury R, Bernauer W (1997) Diagnosis of MALT lymphoma by conjunctival biopsy: a case report. Graefes Arch Clin Exp Ophthalmol 235:606–609PubMedCrossRef
17.
Lee DH, Sohn HW, Park SH, Kang YK (2001) Bilateral conjunctival mucosa-associated lymphoid tissue lymphoma misdiagnosed as allergic conjunctivitis. Cornea 20:427–429PubMedCrossRef
18.
Leff SR, Shields JA, Augsburger JJ, Miller RV, Liberatore B (1985) Unilateral eyelid, conjunctival, and choroidal tumours as initial presentation of diffuse large-cell lymphoma. Br J Ophthalmol 69:861–864PubMed
19.
Looi A, Gascoyne RD, Chhanabhai M, Connors JM, Rootman J, White VA (2005) Mantle cell lymphoma in the ocular adnexal region. Ophthalmology 112:114–119PubMedCrossRef
20.
Matteucci C, Galieni P, Leoncini L, Lazzi S, Lauria F, Polito E, Martelli MF, Mecucci C (2003) Typical genomic imbalances in primary MALT lymphoma of the orbit. J Pathol 200:656–660PubMedCrossRef
21.
Meunier J, Lumbroso-Le Rouic L, Vincent-Salomon A, Dendale R, Asselain B, Arnaud P, Fourquet A, Desjardins L, Plancher C, Validire P, Chaoui D, Levy C, Decaudin D (2004) Ophthalmologic and intraocular non-Hodgkin’s lymphoma: a large single centre study of initial characteristics, natural history, and prognostic factors. Hematol Oncol 22:143–158 (Review)PubMedCrossRef
22.
Petrella T, Bron A, Foulet A, Arnould L, Chirpaz L, Michiels R (1991) Report of a primary lymphoma of the conjunctiva. A lymphoma of MALT origin? Pathol Res Pract 187:78–84PubMed
23.
Reiser M, Josting A, Diehl V, Engert A (2001) Primary lymphoma of the conjunctiva—a rare manifestation of indolent non-Hodgkin’s lymphoma. Ann Hematol 80:311–313PubMedCrossRef
24.
Sasai K, Yamabe H, Dodo Y, Kashii S, Nagata Y, Hiraoka M (2001) Non-Hodgkin’s lymphoma of the ocular adnexa. Acta Oncol 40:485–490PubMedCrossRef
25.
Schick U, Lermen O, Unsold R, Hassler W (2004) Treatment of primary orbital lymphomas. Eur J Haematol 72:186–192PubMedCrossRef
26.
Sharara N, Holden JT, Wojno TH, Feinberg AS, Grossniklaus HE (2003) Ocular adnexal lymphoid proliferations: clinical, histologic, flow cytometric, and molecular analysis of forty-three cases. Ophthalmology 10:1245–1254CrossRef
27.
Vandenberghe E, De Wolf-Peeters C, Vaughan Hudson G, Vaughan Hudson B, Pittaluga S, Anderson L, Linch DC (1997) The clinical outcome of 65 cases of mantle cell lymphoma initially treated with non-intensive therapy by the British National Lymphoma Investigation Group. Br J Haematol 99:842–847PubMedCrossRef
28.
White WL, Ferry JA, Harris NL, Grove AS Jr (1995) Ocular adnexal lymphoma. A clinicopathologic study with identification of lymphomas of mucosa-associated lymphoid tissue type. Ophthalmology 102:1994–2006PubMed
29.
Wotherspoon AC, Diss TC, Pan LX, Schmid C, Kerr-Muir MG, Lea SH, Isaacson PG (1993) Primary low-grade B-cell lymphoma of the conjunctiva: a mucosa-associated lymphoid tissue type lymphoma. Histopathology 23:417–424PubMedCrossRef
Metadata
Title
Primary mantle cell lymphoma of the conjunctiva: a case report
Authors
Miltiadis Aspiotis
Spiridon Gorezis
Ioannis Asproudis
Elena Tsanou
Evangelos Papadiotis
Sevasti Kamina
Niki J. Agnantis
Maria Bai
Publication date
01-10-2006
Publisher
Springer-Verlag
Published in
Virchows Archiv / Issue 4/2006
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI
https://doi.org/10.1007/s00428-006-0268-4

Other articles of this Issue 4/2006

Virchows Archiv 4/2006 Go to the issue

Original Article

Sarcomatoid carcinomas of the lung—are these histogenetically heterogeneous tumors?

Case Report

Sebaceous carcinoma of the breast: case report and review of the literature

Original Article

Impact of pathology review of stage and margin status of radical prostatectomy specimens (EORTC trial 22911)

Original Article

Tissue microarray profiling of primary and xenotransplanted synovial sarcomas demonstrates the immunophenotypic similarities existing between SYT-SSX fusion gene confirmed, biphasic, and monophasic fibrous variants

Original Article

TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system

Letter to the Editor

Chondrosarcomatous differentiation of a metastatic leiomyosarcoma of the uterus