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01-09-2006 | Case Report

Tumor of the liver (hepatocellular and high grade neuroendocrine carcinoma): a case report and review of the literature

Authors: Monica T. Garcia, Pablo A. Bejarano, Maria Yssa, Efren Buitrago, Alan Livingstone

Published in: Virchows Archiv | Issue 3/2006

Abstract

We describe a rare hepatic collision tumor composed of a hepatocellular carcinoma and a high-grade neuroendocrine carcinoma. The patient, a 50-year-old man, underwent a partial hepatectomy because of a 5.0-cm mass. The tumor had two distinctive patterns. The majority of the tumor was a high-grade neuroendocrine carcinoma with features of a small cell carcinoma that was positive for chromogranin, synaptophysin, and cytokeratin 19 and negative for hepatocellular antigen and alpha-fetoprotein (AFP). The second component was a moderately differentiated hepatocellular carcinoma that was positive for hepatocellular antigen and AFP and negative for neuroendocrine markers. The two tumors were separated by fibrous bands. In areas where they collided, there was no transition or intermingling of cells between the two components, thus, it is different from the combined type of tumors. After removal of the tumor, the patient had intrahepatic and mesenteric recurrences within a follow-up period of 16 months.

Barsky SH, Linnoila I, Triche, TJ, Costa J (1984) Hepatocellular carcinoma with carcinoid features. Hum Pathol 15(9):892–894PubMedCrossRef

Goodman ZD, Ishak KG, Langloss JM, Sesterhenn IA, Rabin L (1985) Combined hepatocellular-cholangiocarcinoma. A histologic and immunohistochemical study. Cancer 55(1):124–135PubMedCrossRef

Haratake J, Hashimoto H (1995) An immunohistochemical analysis of 13 cases with combined hepatocellular and cholangiocellularcarcinoma. Liver 15(1):9–15PubMed

Ishida M, Seki K, Tatsuzawa A, Katayama K, Hirose K, Azuma T, Imamura Y, Abraham A, Yamaguchi A (2003) Primary hepatic neuroendocrine carcinoma coexisting with hepatocellular carcinoma in hepatitis C liver cirrhosis: report of a case. Surg Today 33(3):214–218PubMedCrossRef

Jarnagin WR, Weber S, Tickoo SK, Koea JB, Obiekwe S, Fong Y, DeMatteo RP, Blumgart LH, Klimstra D (2002) Combined hepatocellular and cholangiocarcinoma: demographic, clinical, and prognostic factors. Cancer 94(7):2040–2046PubMedCrossRef

Monto A, Wright TL (2001) The epidemiology and prevention of hepatocellular carcinoma. Semin Oncol 28(5):441–449PubMedCrossRef

Morimoto H, Takada Y, Akita T, Kato Y, Tanigawa N, Muraoka R, Urata Y (1986) A resected case of collision tumor of hepatocellular carcinoma and primary liver rhabdomyosarcoma. J Jpn Surg Soc 87(4):456–463

Nzeako UC, Goodman ZD, Ishak KG (1996) Hepatocellular carcinoma in cirrhotic and noncirrhotic livers. A clinico-histopathologic study of 804 North American patients. Am J Clin Pathol 105(1):65–75PubMed

Pilichowska M, Kimura N, Ouchi A, Lin H, Mizuno Y, Nagura H (1999) Primary hepatic carcinoid and neuroendocrine carcinoma: clinicopathological and immunohistochemical study of five cases. Pathol Int 49(4):318–324PubMedCrossRef

10.

Roskams T, Van den Oord JJ, De Vos R, Desmet VJ (1990) Neuroendocrine features of reactive bile ductules in cholestatic liver disease. Am J Clin Pathol 137(5):1019–1025

11.

Roskams T, Cassiman D, De Vos R, Libbrecht L (2004) Neuroregulation of the neuroendocrine compartment of the liver. Anat Rec A Discov Mol Cel Evol Biol 280(1):910–923CrossRef

12.

Rückert RI, Rückert JC, Dörffel Y, Rudolph B, Müller JM (1999) Primary hepatic neuroendocrine tumor: successful hepatectomy in two cases and review of the literature. Digestion 60(2):110–116PubMedCrossRef

13.

Theise ND, Yao JL, Harada K, Hytiroglou P, Portmann B, Thung SN, Tsui W, Ohta H, Nakanuma Y (2003) Hepatic “stem cell” malignancies in adults: four cases. Histopathology 43(3):263–271PubMedCrossRef

14.

Wang J, Dhillon AP, Sankey EA, Wightman AK, Lewin JF, Scheuer PJ (1991) “Neuroendocrine” differentiation in primary neoplasms of the liver. J Pathol 163(1):61–67PubMedCrossRef

15.

Yamaguchi R, Nakashima O, Ogata T, Hanada K, Kumabe T, Kojiro M (2004) Hepatocellular carcinoma with an unusual neuroendocrine component. Pathol Int 54(11):861–865PubMedCrossRef

16.

Zhao M, Laissue JA, Zimmermann A (1993) “Neuroendocrine” differentiation in hepatocellular carcinomas (HCCs): immunohistochemical reactivity is related to distinct tumor cell types, but not to tumor grade. Histol Histopathol 8(4):617–626PubMed

Title: Tumor of the liver (hepatocellular and high grade neuroendocrine carcinoma): a case report and review of the literature
Authors: Monica T. Garcia
Pablo A. Bejarano
Maria Yssa
Efren Buitrago
Alan Livingstone
Publication date: 01-09-2006
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 3/2006
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-006-0251-0

At a glance: The STEP trials

Springer Medicine

Tumor of the liver (hepatocellular and high grade neuroendocrine carcinoma): a case report and review of the literature

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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