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Virchows Archiv
Published in: Virchows Archiv 2/2006

01-08-2006 | Case Report

Extramammary myofibroblastoma is genetically related to spindle cell lipoma

Authors: Francesca Maggiani, Maria Debiec-Rychter, Guy Verbeeck, Raf Sciot

Published in: Virchows Archiv | Issue 2/2006

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Abstract

Extramammary-type myofibroblastoma is a rare, benign spindle cell lesion, strictly resembling the breast counterpart, but occurring in extramammary sites, mainly in the inguinal/groin area. In this paper, we describe an extramammary-type myofibroblastoma in the groin of a 37-year-old male patient. The tumor showed a typical morphological and immunophenotypical profile, including staining for both CD34 and desmin. Dual-color interphase florescent in situ hybridization analysis revealed losses of RB/13q14 and FKHR/13q14 loci within tumor cells. The chromosome 13 rearrangements associated with the loss of the 13q14 chromosomal region are typically seen in spindle cell lipoma, and have been previously recognized in mammary myofibroblastoma, providing strong evidence for a pathogenetic link between these lesions.
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Metadata
Title
Extramammary myofibroblastoma is genetically related to spindle cell lipoma
Authors
Francesca Maggiani
Maria Debiec-Rychter
Guy Verbeeck
Raf Sciot
Publication date
01-08-2006
Publisher
Springer-Verlag
Published in
Virchows Archiv / Issue 2/2006
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI
https://doi.org/10.1007/s00428-006-0228-z

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