Top

Published in:

01-08-2006 | Original Article

CD10 expression by fusiform stromal cells in nasopharyngeal carcinoma correlates with tumor progression

Authors: Hend Braham, Mounir Trimeche, Sonia Ziadi, Sarra Mestiri, Moncef Mokni, Khaled Amara, Mohamed Hachana, Badreddine Sriha, Sadok Korbi

Published in: Virchows Archiv | Issue 2/2006

Abstract

CD10 is a cell surface zinc metalloprotease expressed through a variety of normal cell types, including lymphoid precursor cells, germinal center B lymphocytes, and some epithelial cells. Many studies showed that CD10 expression is associated with the tumor progression of a large variety of cancers, such as breast and colorectal carcinomas. The aim of this study was to investigate the expression of CD10 in nasopharyngeal carcinoma (NPC). The expression of CD10 was immunohistochemically examined in 47 paraffin embedded NPC biopsies from Tunisian patients compared with 16 reactional nasopharyngeal mucosas. A significant expression of CD10 was observed in stromal fusiform cells in 46.8% of NPC cases but was not in malignant and normal epithelial cells. There was no significant expression of CD10 in control group. The stromal expression of CD10 was more frequently detected in advanced clinical stage than early stage (56 vs 23%; p=0.04) and in patients older than 25 years than in patients under 25 years (56.2 vs 26.5%; p=0.05). Our study is the first in investigating CD10 expression in nasopharyngeal carcinoma and showed that CD10 expression by stromal cells in this malignancy play an important role in tumor progression, particularly in older patients.

Barnes L, Eveson JW, Reichart P, Sidransky D (eds) (2005) World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. IARC Press, Lyon

Bilalovic N, Sandstad B, Golouh R, Nesland JM, Selak I, Torlakovic EE (2004) CD10 protein expression in tumor and stromal cells of malignant melanoma is associated with tumor progression. Mod Pathol 17:1251–1258PubMedCrossRef

Cammoun M, Hoerner V, Mourali N (1974) Tumors of the nasopharynx in Tunisia. An anatomic and clinical study based on 143 cases. Cancer 33:184–192PubMedCrossRef

Casey ML, Smith JW, Nagai K, MacDonald PC (1993) Transforming growth factor-beta 1 inhibits enkephalinase (EC 3.4.24.11) gene expression in human endometrial stromal cells and sex skin fibroblasts in culture. J Clin Endocrinol Metab 77:144–150PubMedCrossRef

Chu P, Arber DA (2000) Paraffin-section detection of CD10 in 505 nonhematopoietic neoplasms. Frequent expression in renal cell carcinoma and endometrial stromal sarcoma. Am J Clin Pathol 113:374–382PubMedCrossRef

Cohen AJ, Bunn PA, Franklin W, Magill-Solc C, Hartmann C, Helfrich B, Gilman L, Folkvord J, Helm K, Miller YE (1996) Neutral endopeptidase: variable expression in human lung, inactivation in lung cancer, and modulation of peptide-induced calcium flux. Cancer Res 56:831–839PubMed

Cutrona G, Leanza N, Ulivi M, Melioli G, Burgio VL, Mazzarello G, Gabutti G, Roncella S, Ferrarini M (1999) Expression of CD10 by human T cells that undergo apoptosis both in vitro and in vivo. Blood 94:3067–3076PubMed

Egeblad M, Werb Z (2002) New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2:161–174PubMedCrossRef

Gohring B, Holzhausen HJ, Meye A, Heynemann H, Rebmann U, Langner J, Riemann D (1998) Endopeptidase 24.11/CD10 is down-regulated in renal cell cancer. Int J Mol Med 2:409–414PubMed

10.

Greaves MF, Hariri G, Newman RA, Sutherland DR, Ritter MA, Ritz J (1983) Selective expression of the common acute lymphoblastic leukemia (gp 100) antigen on immature lymphoid cells and their malignant counterparts. Blood 61:628–639PubMed

11.

Horikawa T, Yoshizaki T, Sheen TS, Lee SY, Furukawa M (2000) Association of latent membrane protein 1 and matrix metalloproteinase 9 with metastasis in nasopharyngeal carcinoma. Cancer 89:715–723PubMedCrossRef

12.

Iwaya K, Ogawa H, Izumi M, Kuroda M, Mukai K (2002) Stromal expression of CD10 in invasive breast carcinoma: a new predictor of clinical outcome. Virchows Arch 440:589–593PubMedCrossRef

13.

Jaffe ES, Harris NL, Stein H, Vardiman JW (eds) (2001) World Health Organization classification of tumors. Pathology and genetics of tumors of haematopoietic and lymphoid tissues. IARC Press, Lyon

14.

Jeannel D, Bouvier G, Hubert A (1999) Nasopharyngeal carcinoma: an epidemiological approach to carcinogenesis. Cancer Surv 33:125–155

15.

Karray H, Ayadi W, Fki L, Hammami A, Daoud J, Drira MM, Frikha M, Jlidi R, Middeldorp JM (2005) Comparison of three different serological techniques for primary diagnosis and monitoring of nasopharyngeal carcinoma in two age groups from Tunisia. J Med Virol 75:593–602PubMedCrossRef

16.

Kenny AJ, O’Hare MJ, Gusterson BA (1989) Cell-surface peptidases as modulators of growth and differentiation. Lancet 30:785–787CrossRef

17.

Khabir A, Sellami A, Sakka M, Ghorbel AM, Daoud J, Frikha M, Drira MM, Busson P, Jlidi R (2000) Contrasted frequencies of p53 accumulation in the two age groups of North African nasopharyngeal carcinomas. Clin Cancer Res 6:3932–3936PubMed

18.

Khabir A, Ghorbel A, Daoud J, Frikha M, Drira MM, Laplanche A, Busson P, Jlidi R (2003) Similar BCL-X but different BCL-2 levels in the two age groups of North African nasopharyngeal carcinomas. Cancer Detect Prev 27:250–255PubMedCrossRef

19.

Khabir A, Karray H, Rodriguez S et al (2005) EBV latent membrane protein 1 abundance correlates with patient age but not with metastatic behavior in North African nasopharyngeal carcinomas. J Virol 2:39–46CrossRef

20.

Koiso K, Akaza H, Ohtani M, Miyanaga N, Aoyagi K (1994) A new tumor marker for bladder cancer. Int J Urol 1:33–36PubMedCrossRef

21.

Kondepudi A, Johnson A (1993) Cytokines increase neutral endopeptidase activity in lung fibroblasts. Am J Respir Cell Mol Biol 8:43–49PubMed

22.

Kondo S, Wakisaka N, Schell MJ, Horikawa T, Sheen TS, Sato H, Furukawa M, Pagano JS, Yoshizaki T (2005) Epstein–Barr virus latent membrane protein 1 induces the matrix metalloproteinase-1 promoter via an Ets binding site formed by a single nucleotide polymorphism: enhanced susceptibility to nasopharyngeal carcinoma. Int J Cancer 115:368–376PubMedCrossRef

23.

Liotta LA, Stetler-Stevenson WG (1991) Tumor invasion and metastasis: an imbalance of positive and negative regulation. Cancer Res 51(supp l):5054–5059

24.

McCawley LJ, Matrisian LM (2000) Matrix metalloproteinases: multifunctional contributors to tumor progression. Mol Med Today 6:149–156PubMedCrossRef

25.

Ogawa H, Iwaya K, Izumi M, Kuroda M, Serizawa H, Koyanagi Y, Mukai K (2002) Expression of CD10 by stromal cells during colorectal tumor development. Hum Pathol 33:806–811PubMedCrossRef

26.

Parkin DM, Whelan SL, Ferlay J, Raymond L, Youg J (eds) (1997) Cancer incidence in five continents, vol VII. IARC Scientific Publication No. 143. IARC Press, Lyon

27.

Pekonen F, Nyman T, Ammala M, Rutanen EM (1995) Decreased expression of messenger RNAs encoding endothelin receptors and neutral endopeptidase 24.11 in endometrial cancer. Br J Cancer 71:59–63PubMed

28.

Potlog-Nahari C, Feldman AL, Stratton P, Koziol DE, Segars J, Merino MJ, Nieman LK (2004) CD10 immunohistochemical staining enhances the histological detection of endometriosis. Fertil Steril 82:86–92PubMedCrossRef

29.

Sato Y, Itoh F, Hinoda Y, Ohe Y, Nakagawa N, Ueda R, Yachi A, Imai K (1996) Expression of CD10/neutral endopeptidase in normal and malignant tissues of the human stomach and colon. J Gastroenterol 31:12–17PubMedCrossRef

30.

Shipp MA, Look AT (1993) Hematopoietic differentiation antigens that are membrane-associated enzymes: cutting is the key! Blood 82:1052–1070PubMed

31.

Shipp MA, Tarr GE, Chen CY, Switzer SN, Hersh LB, Stein H, Sunday ME, Reinherz EL (1991) CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung. Proc Natl Acad Sci USA 188:10662–10666CrossRef

32.

Sternlicht MD, Lochter A, Sympson CJ, Huey B, Rougier JP, Gray JW, Pinkel D, Bissell MJ, Werb Z (1999) The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis. Cell 98:137–146PubMedCrossRef

33.

Tawfic S, Niehans GA, Manivel JC (2003) The pattern of CD10 expression in selected pathologic entities of the prostate gland. Hum Pathol 34:450–456PubMedCrossRef

34.

Tran NL, Nagle RB, Cress AE, Heimark RL (1999) N-Cadherin expression in human prostate carcinoma cell lines. An epithelial–mesenchymal transformation mediating adhesion with Stromal cells. Am J Pathol 155:787–798PubMed

35.

Trimeche M, Ziadi S, De Leval L, Hmissa S, Sriha B, Mokni M, Toumi I, Elomri H, Laatiri A, Kehlif A, Boniver J, Korbi S (2005) Prevalence of Epstein–Barr virus in non-Hodgkin’s lymphomas in central region of Tunisia. Ann Pathol 25:95–102PubMedCrossRef

Title: CD10 expression by fusiform stromal cells in nasopharyngeal carcinoma correlates with tumor progression
Authors: Hend Braham
Mounir Trimeche
Sonia Ziadi
Sarra Mestiri
Moncef Mokni
Khaled Amara
Mohamed Hachana
Badreddine Sriha
Sadok Korbi
Publication date: 01-08-2006
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 2/2006
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-006-0217-2

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

CD10 expression by fusiform stromal cells in nasopharyngeal carcinoma correlates with tumor progression

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 2/2006

A murine model of NKT cell-mediated liver injury induced by alpha-galactosylceramide/d-galactosamine

Immunohistochemical evaluation of a novel clone of monoclonal anti-MYCN antibody B8.4B in neuroblastic tumours: a correlation with MYCN gene status

C4d deposits mark sites of meniscal tissue disintegration

Nonhypotensive dose of β-adrenergic blocker ameliorates capillary deficits in the hearts of rats with moderate renal failure

The cardiac isoform of α-actin in regenerating and atrophic skeletal muscle, myopathies and rhabdomyomatous tumors: an immunohistochemical study using monoclonal antibodies

Extramammary myofibroblastoma is genetically related to spindle cell lipoma