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01-10-2005 | Original Article

Immunolocalization and distribution patterns of type IV collagen alpha chains in oral mucosal melanoma

Authors: Hitoshi Nagatsuka, Rosario Santos Rivera, Mehmet Gunduz, You-Jin Lee, Ryo Tamamura, Esra Gunduz, Ichiro Naito, Yoshikazu Sado, Noriyuki Nagai

Published in: Virchows Archiv | Issue 4/2005

Abstract

The basement membrane (BM) is mainly composed of type IV collagen, which is composed of triple combinations of six distinct alpha (α) chains in a tissue-specific manner. The six collagen chain-specific antibodies (α1–α6) were used to examine the BMs of the oral epithelium (OE) and tumor clusters in oral mucosal melanoma (OMM). Eight OMM cases were examined. Results showed that the α1 and α2 chains were constantly detected at the BM of the normal OE as well as at the OE with atypical melanocytic proliferation and in invasive melanoma with nodular nests. The α1 and α2 chains were intermittently detected in in situ OMM, early invasive OMM and advanced invasive OMM with sheet-like nests. Gradual loss of α5 and α6 from the OE with atypical melanocyte through in situ OMM and early invasive OMM was observed. These findings suggest that changes in the immunolocalization and distribution patterns of type IV collagen α chains are associated with the progression of OMM. The distribution pattern of type IV collagen α chain varies depending on the architecture of the nest.

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Title: Immunolocalization and distribution patterns of type IV collagen alpha chains in oral mucosal melanoma
Authors: Hitoshi Nagatsuka
Rosario Santos Rivera
Mehmet Gunduz
You-Jin Lee
Ryo Tamamura
Esra Gunduz
Ichiro Naito
Yoshikazu Sado
Noriyuki Nagai
Publication date: 01-10-2005
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 4/2005
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-005-0016-1

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Immunolocalization and distribution patterns of type IV collagen alpha chains in oral mucosal melanoma

Abstract

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