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Virchows Archiv
Published in: Virchows Archiv 6/2004

01-12-2004 | Case Report

Malignant transformation of sialadenoma papilliferum of the palate: a case report

Authors: Masayuki Shimoda, Kaori Kameyama, Shojiroh Morinaga, Youichi Tanaka, Kazuhiro Hashiguchi, Megumi Shimada, Yasunori Okada

Published in: Virchows Archiv | Issue 6/2004

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Abstract

We report a case of a 79-year-old woman with an unusual salivary gland tumor that developed at the junction between the soft and hard palates. The tumor consisted of sialadenoma papilliferum (SP) with areas of an epithelial–myoepithelial carcinoma (EMC) component and a high-grade carcinoma component. There were also transitional regions among the SP, the EMC and the high-grade carcinoma components. The high-grade carcinoma component, which was similar to invasive micropapillary carcinoma of the breast, infiltrated into the right parapharyngeal space and metastasized to the lungs and cervical vertebrae. The high-grade carcinoma cells were positively immunostained for p53 protein. SP has been considered to be a benign tumor with exceptionally good prognosis, and, to the best of our knowledge, there has never been a confirmed case of malignant SP. This is the first report of SP with a definite malignant component.
Literature
1.
Abrams AM, Flinck FM (1969) Sialadenoma papilliferum. A previously unreported salivary gland tumor. Cancer 24:1057–1063PubMed
2.
Alos L, Carrilo R, Ramos J, Baez JM, Mallofre C, Fernandez PL, Cardesa A (1999) High-grade carcinoma component in epithelial-myoepithelial carcinoma of salivary glands clinicopathological, immunohistochemical and flow-cytometric study of three cases. Virchows Arch 434:291–299CrossRefPubMed
3.
Asahina I, Abe M (1997) Sialadenoma papilliferum of the hard palate: a case report and review of literature. J Oral Maxillofac Surg 55:1000–1003CrossRefPubMed
4.
Chau Y, Hongyo T, Aozasa K, Chan JK (2001) Dedifferentiation of adenoid cystic carcinoma: report of a case implicating p53 gene mutation. Hum Pathol 32:1403–1407CrossRefPubMed
5.
Cheuk W, Chan J, Ngan RKC (1999) Dedifferentiation in adenoid cystic carcinoma of salivary gland. A common complication associated with an accelerated clinical course. Am J Surg Pathol 23:465–472CrossRefPubMed
6.
Dahlin DC, Beabout JW (1971) Dedifferentiation in low-grade chondrosarcoma. Cancer 28:461–466PubMed
7.
Di Palma S, Corletto V, Lovarino C Birindelli S, Pilotti S (1999) Unilateral aneuploid dedifferentiated acinic cell carcinoma associated with bilateral low-grade diploid acinic cell carcinoma of the parotid gland. Virchows Arch 434:361–365CrossRefPubMed
8.
Di Palma S, Corletto V, Lovarino C, Birindelli, Pilotti S (2000) Dedifferentiation in salivary gland carcinoma. Am J Surg Pathol 24:1439–1440PubMed
9.
Ellis GL, Auclair PL (1995) Tumors of the salivary glands. Armed Forced Institute of Pathology, Washington, DC
10.
Evans HL (1979) Liposarcoma: a study of 55 cases with a reassessment of its classification. Am J Surg Pathol 3:507–523PubMed
11.
Fantasia JE, Nocco CE, Lally ET (1986) Ultrastructure of sialadenoma papilliferum. Arch Pathol Lab Med 110:523–527PubMed
12.
Fonseca I, Felix A, Soarses J (2000) Dedifferentiation in salivary gland carcinoma. Am J Surg Pathol 24:469–471CrossRefPubMed
13.
Foschini MP, Eusebi V (1998) Carcinomas of the breast showing myoepithelial cell differentiation. A review of the literature. Virchows Arch 432:303–310CrossRefPubMed
14.
Gallo O, Franchi A, Bianchi S, Boddi V, Giannelli E, Alajmo E (1995) p53 oncoprotein expression in parotid gland carcinoma is associated with clinical outcome. Cancer 75:2037–2044PubMed
15.
Henley JD, Geary WA, Jackson CL, Wu CD, Gnepp DR (1997) Dedifferentiated acinic cell carcinoma of the parotid gland: a distinct rarely described entity. Hum Pathol 28:869–873CrossRefPubMed
16.
Maiorano E, Favia G, Ricco R (1996) Sialadenoma papilliferum: an immunohistochemical study of five cases. J Oral Pathol Med 25:336–342PubMed
17.
Meis JM (1991) “Dedifferentiation” in bone and soft tissue tumors: a histological indicator of tumor progression. Pathol Annu 26:37–62PubMed
18.
Michal M, Skalova A, Mukensnabl P (2000) Micropapillary carcinoma of the parotid gland arising in mucinous cystadenoma. Virchows Arch 437:465–468CrossRefPubMed
19.
Mills SE, Garland TA, Allen MS (1984) Low-grade papillary adenocarcinoma of palatal salivary gland origin. Am J Surg Pathol 8:367–374PubMed
20.
Mostofi R, Wood RS, Christison W, Talerman A (1992) Low-grade papillary adenocarcinoma of minor salivary glands. Case report and literature review. Oral Surg Oral Med Oral Pathol 73:591–595PubMed
21.
Nakahata A, Deguchi H, Yanagawa T, Yoshida H, Sato M, Hayashi Y (1990) Coexpression of intermediate-sized filaments in sialadenoma papilliferum and other salivary gland neoplasms. J Oral Pathol Med 19:313–318PubMed
22.
Piana S, Cavazza A, Pedroni C, Scotti R, Serra L, Gardini G (2002) Dedifferentiated acinic cell carcinoma of the parotid gland with myoepithelial features. Arch Pathol Lab Med 126:1104–1105PubMed
23.
Pimentel MT, Lopez Amado M, Garcia Sarandeses (1995) A Recurrent sialadenoma papilliferum of the buccal mucosa. J Laryngol Otol 109:787–790PubMed
24.
Rennie JS, MacDonald DG, Critchlow HA (1984) Sialadenoma papilliferum. A case report and review of the literature. Int J Oral Surg 13:452–454PubMed
25.
Shirasuna K, Watatani K, Miyazaki T (1984) Ultrastructure of a sialadenoma papilliferum. Cancer 53:468–474PubMed
26.
Simpson RH, Prasad AR, Lewis JE, Skalova A, David L (2003) Mucin-rich variant of salivary duct carcinoma: a clinicopathologic and immunohistochemical study of four cases. Am J Surg Pathol 27:1070–1079
27.
Solomon MP, Rosen Y, Alfonso A (1978) Intraoral papillary squamous cell tumor of the soft palate with features of sialadenoma papilliferum-? malignant sialadenoma papilliferum. Cancer 42:1859–1869PubMed
28.
Stanley RJ, Weiland LH, Olsen KD, Pearson BW (1988) Dedifferentiated acinic cell (acinous) carcinoma of the parotid gland. Otolaryngol Head Neck Surg 98:155–161PubMed
29.
Ubaidat MA, Robinson RA, Belding PJ, Merryman DJ (2001) Sialadenoma papilliferum of the hard palate: report of 2 cases and immunohistochemical evaluation. Arch Pathol Lab Med 125:1595–1597PubMed
Metadata
Title
Malignant transformation of sialadenoma papilliferum of the palate: a case report
Authors
Masayuki Shimoda
Kaori Kameyama
Shojiroh Morinaga
Youichi Tanaka
Kazuhiro Hashiguchi
Megumi Shimada
Yasunori Okada
Publication date
01-12-2004
Publisher
Springer-Verlag
Published in
Virchows Archiv / Issue 6/2004
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI
https://doi.org/10.1007/s00428-004-1091-4

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