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01-07-2004 | Review Article

Fibrosis of the pancreas: the initial tissue damage and the resulting pattern

Authors: Günter Klöppel, Sönke Detlefsen, Bernd Feyerabend

Published in: Virchows Archiv | Issue 1/2004

Abstract

Fibrosis in the pancreas is caused by such processes as necrosis/apoptosis, inflammation or duct obstruction. The initial event that induces fibrogenesis in the pancreas is an injury that may involve the interstitial mesenchymal cells, the duct cells and/or the acinar cells. Damage to any one of these tissue compartments of the pancreas is associated with cytokine-triggered transformation of resident fibroblasts/pancreatic stellate cells into myofibroblasts and the subsequent production and deposition of extracellular matrix. Depending on the site of injury in the pancreas and the involved tissue compartment, predominantly inter(peri)lobular fibrosis (as in alcoholic chronic pancreatitis), periductal fibrosis (as in hereditary pancreatitis), periductal and interlobular fibrosis (as in autoimmune pancreatitis) or diffuse inter- and intralobular fibrosis (as in obstructive chronic pancreatitis) develops.

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Title: Fibrosis of the pancreas: the initial tissue damage and the resulting pattern
Authors: Günter Klöppel
Sönke Detlefsen
Bernd Feyerabend
Publication date: 01-07-2004
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 1/2004
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-004-1021-5

At a glance: The STEP trials

Springer Medicine

Fibrosis of the pancreas: the initial tissue damage and the resulting pattern

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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