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01-08-2003 | Original Article

Expression of osteoprotegerin correlates with aggressiveness and poor prognosis of gastric carcinoma

Authors: Reiko Ito, Hirofumi Nakayama, Kazuhiro Yoshida, Kazuya Kuraoka, Junichi Motoshita, Noriko Oda, Naohide Oue, Wataru Yasui

Published in: Virchows Archiv | Issue 2/2003

Abstract

Osteoprotegerin (OPG), identical with osteoclastogenesis inhibitory factor, is a member of a subgroup of the tumor necrosis factor (TNF)-receptor superfamily, which functions as a soluble decoy receptor. It has been reported that OPG expression is associated with bone metastasis of cancer of the breast and prostate. In the present study, we examined the expression of OPG in gastric carcinomas using immunohistochemistry and reverse-transcription polymerase chain reaction methods, and compared with clinicopathological parameters. The expression of OPG mRNA was confirmed in a gastric carcinoma cell line (MKN-7) and gastric carcinoma tissues. Immunohistochemically, strongly positive staining of OPG was found in 65% (67/103) of gastric carcinomas, whereas OPG protein was not detected in non-neoplastic mucosal epithelia. The expression of OPG protein in gastric carcinoma tissues correlates significantly with depth of tumor invasion, nodal metastases and advanced tumor stage. Furthermore, the prognosis of the cases with strong OPG expression was significantly worse than those with weak or no expression of OPG. These results suggest that OPG may participate in stomach carcinogenesis, invasion and metastasis, and may serve as a novel molecular marker for aggressive gastric cancer.

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Title: Expression of osteoprotegerin correlates with aggressiveness and poor prognosis of gastric carcinoma
Authors: Reiko Ito
Hirofumi Nakayama
Kazuhiro Yoshida
Kazuya Kuraoka
Junichi Motoshita
Noriko Oda
Naohide Oue
Wataru Yasui
Publication date: 01-08-2003
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 2/2003
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-003-0845-8

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Expression of osteoprotegerin correlates with aggressiveness and poor prognosis of gastric carcinoma

Abstract

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Abstract

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