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Published in: Langenbeck's Archives of Surgery 2/2021

01-03-2021 | Antibiotic | Original Article

Impact of the COVID-19 pandemic on appendicitis treatment in Germany—a population-based analysis

Authors: Franziska Köhler, Laura Acar, Anne van den Berg, Sven Flemming, Carolin Kastner, Sophie Müller, Johannes Diers, Christoph-Thomas Germer, Johann F. Lock, Helmut L’hoest, Ursula Marschall, Armin Wiegering

Published in: Langenbeck's Archives of Surgery | Issue 2/2021

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Abstract

Purpose

Acute appendicitis is one of the most common reasons for emergency medical consultation. While simple appendicitis can be treated with antibiotics or surgery, complex appendicitis including gangrene, abscess, and perforation requires appendectomy. During the COVID-19 pandemic in early 2020, an overall drop in emergency room consultations was observed. We therefore aimed to investigate the incidence and treatment strategies of acute appendicitis during that period.

Methods

Data of insurance holders with the ICD code for “acute appendicitis” or OPS procedure of appendectomy of a major health insurance company in Germany were analyzed retrospectively. Groups were built, containing of the means of March–June of 2017, 2018, and 2019, defined as “pre-COVID group” with the “COVID group,” defined as data from March to June of 2020. Data was analyzed by age, sex, comorbidities, length of hospital stay, diagnoses, and treatment. Data of the COVID group was analyzed for simultaneous COVID-19 infection.

Results

During the COVID-19 pandemic of early 2020, an overall reduction by 12.9% of patients presenting with acute appendicitis was noticeable. These results were mainly due to decreased rates of uncomplicated appendicitis, while complicated appendicitis was scarcely affected. Especially in the group of females < 40 years, a drastic reduction was visible. Rates of extended surgery did not change. Likewise, the complication rate like appendix stump leakage or need for re-operation did not differ. In March 2020, 4.8% of acute appendicitis patients had concomitant COVID-19 infection.

Conclusion

In line with the overall drop of emergency room visits during the COVID-19 pandemic of spring 2020 in Germany, a significantly lowered number of patients with uncomplicated appendicitis were noticeable, whereas complicated appendicitis did not differ. Also, treatment and complication rate of acute appendicitis did not change. These findings might be a hint that acute appendicitis is not a progressing disease but caused by different entities for uncomplicated and complicated appendicitis and therefore another clue that uncomplicated appendicitis can be treated with antibiotics or observation. Nevertheless provided data does not cover outpatient treatment; therefore, no statement observation or antibiotics in outpatients can be made.
Literature
1.
go back to reference Snyder MJ, Guthrie M, Cagle S (2018) Acute appendicitis: efficient diagnosis and management. Am Fam Physician 98(1):25–33PubMed Snyder MJ, Guthrie M, Cagle S (2018) Acute appendicitis: efficient diagnosis and management. Am Fam Physician 98(1):25–33PubMed
2.
go back to reference Bhangu A, Søreide K, Di Saverio S, Assarsson JH, Drake FT (2015) Acute appendicitis: modern understanding of pathogenesis, diagnosis, and management. Lancet. 386(10000):1278–1287CrossRef Bhangu A, Søreide K, Di Saverio S, Assarsson JH, Drake FT (2015) Acute appendicitis: modern understanding of pathogenesis, diagnosis, and management. Lancet. 386(10000):1278–1287CrossRef
3.
go back to reference Jaschinski T, Mosch CG, Eikermann M, Neugebauer EAM, Sauerland S (2018) Laparoscopic versus open surgery for suspected appendicitis. Cochrane Database Syst Rev 2018(11) Jaschinski T, Mosch CG, Eikermann M, Neugebauer EAM, Sauerland S (2018) Laparoscopic versus open surgery for suspected appendicitis. Cochrane Database Syst Rev 2018(11)
4.
go back to reference Ergul E (2007) Heredity and familial tendency of acute appendicitis. Scand J Surg 96(4):290–292CrossRef Ergul E (2007) Heredity and familial tendency of acute appendicitis. Scand J Surg 96(4):290–292CrossRef
5.
go back to reference Sadr Azodi O, Andrén-Sandberg Å, Larsson H (2009) Genetic and environmental influences on the risk of acute appendicitis in twins. Br J Surg 96(11):1336–1340CrossRef Sadr Azodi O, Andrén-Sandberg Å, Larsson H (2009) Genetic and environmental influences on the risk of acute appendicitis in twins. Br J Surg 96(11):1336–1340CrossRef
6.
go back to reference Humes D, Simpson J (2006) Clinical review acute appendicitis. Bmj. 333:530–534CrossRef Humes D, Simpson J (2006) Clinical review acute appendicitis. Bmj. 333:530–534CrossRef
7.
go back to reference Farahbakhsh F, Torabi M, Mirzaee M (2020) A comparative study on the diagnostic validity of three scoring systems in the diagnosis of acute appendicitis in emergency centres. African J Emerg Med 10(3):132–135CrossRef Farahbakhsh F, Torabi M, Mirzaee M (2020) A comparative study on the diagnostic validity of three scoring systems in the diagnosis of acute appendicitis in emergency centres. African J Emerg Med 10(3):132–135CrossRef
8.
go back to reference Marin D, Ho LM, Barnhart H, Neville AM, White RR, Paulson EK (2010) Percutaneous abscess drainage in patients with perforated acute appendicitis: effectiveness, safety, and prediction of outcome. Am J Roentgenol 194(2):422–429CrossRef Marin D, Ho LM, Barnhart H, Neville AM, White RR, Paulson EK (2010) Percutaneous abscess drainage in patients with perforated acute appendicitis: effectiveness, safety, and prediction of outcome. Am J Roentgenol 194(2):422–429CrossRef
9.
go back to reference Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, Liu L, Shan H, Lei CL, Hui DSC, du B, Li LJ, Zeng G, Yuen KY, Chen RC, Tang CL, Wang T, Chen PY, Xiang J, Li SY, Wang JL, Liang ZJ, Peng YX, Wei L, Liu Y, Hu YH, Peng P, Wang JM, Liu JY, Chen Z, Li G, Zheng ZJ, Qiu SQ, Luo J, Ye CJ, Zhu SY, Zhong NS, China Medical Treatment Expert Group for Covid-19 (2020) Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 382(18):1708–1720CrossRef Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, Liu L, Shan H, Lei CL, Hui DSC, du B, Li LJ, Zeng G, Yuen KY, Chen RC, Tang CL, Wang T, Chen PY, Xiang J, Li SY, Wang JL, Liang ZJ, Peng YX, Wei L, Liu Y, Hu YH, Peng P, Wang JM, Liu JY, Chen Z, Li G, Zheng ZJ, Qiu SQ, Luo J, Ye CJ, Zhu SY, Zhong NS, China Medical Treatment Expert Group for Covid-19 (2020) Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 382(18):1708–1720CrossRef
10.
go back to reference Sohrabi C, Alsafi Z, Neill NO, Khan M, Kerwan A (2020) World Health Organization declares global emergency: a review of the 2019 novel coronavirus (COVID-19). Int J Surg 76:71–76CrossRef Sohrabi C, Alsafi Z, Neill NO, Khan M, Kerwan A (2020) World Health Organization declares global emergency: a review of the 2019 novel coronavirus (COVID-19). Int J Surg 76:71–76CrossRef
11.
go back to reference Li X, Xu Z, Wang T, Xu X, Li H, Sun Q et al (2020) Clinical laboratory characteristics of severe patients with coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis Xiang. Clin Epidemiol Glob Health Li X, Xu Z, Wang T, Xu X, Li H, Sun Q et al (2020) Clinical laboratory characteristics of severe patients with coronavirus disease 2019 (COVID-19): a systematic review and meta-analysis Xiang. Clin Epidemiol Glob Health
14.
go back to reference Flemming S, Hankir M, Ernestus RI, Seyfried F, Germer CT, Meybohm P, Wurmb T, Vogel U, Wiegering A (2020) Surgery in times of COVID-19—recommendations for hospital and patient management. Langenbeck's Arch Surg 405(3):359–364CrossRef Flemming S, Hankir M, Ernestus RI, Seyfried F, Germer CT, Meybohm P, Wurmb T, Vogel U, Wiegering A (2020) Surgery in times of COVID-19—recommendations for hospital and patient management. Langenbeck's Arch Surg 405(3):359–364CrossRef
15.
go back to reference Sahm M, Koch A, Schmidt U, Wolff S, Pross M, Gastinger I, Lippert H (2013) Akute Appendizitis - Klinische Versorgungsforschung zur aktuellen chirurgischen Therapie. Zentralbl Chir 138(3):270–277PubMed Sahm M, Koch A, Schmidt U, Wolff S, Pross M, Gastinger I, Lippert H (2013) Akute Appendizitis - Klinische Versorgungsforschung zur aktuellen chirurgischen Therapie. Zentralbl Chir 138(3):270–277PubMed
16.
go back to reference Slagman A, Behringer W, Greiner F, Klein M, Weismann D, Erdmann B et al (2020) Medizinische Notfälle während der COVID-19-Pandemie. Dtsch Arztebl Int 117(34–34):545–552PubMedPubMedCentral Slagman A, Behringer W, Greiner F, Klein M, Weismann D, Erdmann B et al (2020) Medizinische Notfälle während der COVID-19-Pandemie. Dtsch Arztebl Int 117(34–34):545–552PubMedPubMedCentral
17.
go back to reference Baum P, Diers J, Lichthardt S, Kastner C, Schlegel N, Germer CT, Wiegering A (2019) Originalarbeit Sterblichkeit und Komplikationen nach viszeralchirurgischen Operationen. Dtsch Arztebl Int 116(44):739–746PubMedPubMedCentral Baum P, Diers J, Lichthardt S, Kastner C, Schlegel N, Germer CT, Wiegering A (2019) Originalarbeit Sterblichkeit und Komplikationen nach viszeralchirurgischen Operationen. Dtsch Arztebl Int 116(44):739–746PubMedPubMedCentral
18.
go back to reference The Coda Collaborative (2020) A randomized trial comparing antibiotics with appendectomy for appendicitis. N Engl J Med [Internet] NEJMoa2014320 The Coda Collaborative (2020) A randomized trial comparing antibiotics with appendectomy for appendicitis. N Engl J Med [Internet] NEJMoa2014320
19.
go back to reference Harnoss JC, Zelienka I, Probst P, Grummich K, Müller-Lantzsch C, Harnoss JM, Ulrich A, Büchler MW, Diener MK (2017) Antibiotics versus surgical therapy for uncomplicated appendicitis: systematic review and meta-analysis of controlled trials (PROSPERO 2015:CRD42015016882). Ann Surg 265(5):889–900CrossRef Harnoss JC, Zelienka I, Probst P, Grummich K, Müller-Lantzsch C, Harnoss JM, Ulrich A, Büchler MW, Diener MK (2017) Antibiotics versus surgical therapy for uncomplicated appendicitis: systematic review and meta-analysis of controlled trials (PROSPERO 2015:CRD42015016882). Ann Surg 265(5):889–900CrossRef
20.
go back to reference Poillucci G, Mortola L, Podda M, Di Saverio S, Casula L, Gerardi C et al (2017) Laparoscopic appendectomy vs antibiotic therapy for acute appendicitis: a propensity score-matched analysis from a multicenter cohort study. Updat Surg 69(4):531–540CrossRef Poillucci G, Mortola L, Podda M, Di Saverio S, Casula L, Gerardi C et al (2017) Laparoscopic appendectomy vs antibiotic therapy for acute appendicitis: a propensity score-matched analysis from a multicenter cohort study. Updat Surg 69(4):531–540CrossRef
21.
go back to reference Styrud J, Eriksson S, Nilsson I, Ahlberg G, Haapaniemi S, Neovius G, Rex L, Badume I, Granström L (2006) Appendectomy versus antibiotic treatment in acute appendicitis. A prospective multicenter randomized controlled trial. World J Surg 30(6):1033–1037CrossRef Styrud J, Eriksson S, Nilsson I, Ahlberg G, Haapaniemi S, Neovius G, Rex L, Badume I, Granström L (2006) Appendectomy versus antibiotic treatment in acute appendicitis. A prospective multicenter randomized controlled trial. World J Surg 30(6):1033–1037CrossRef
22.
go back to reference Loftus TJ, Raymond SL, Sarosi GA Jr, Croft A, Smith RS, Efron PA et al (2017) Predicting appendiceal tumors among patients with appendicitis. J Trauma Acute Care Surg 82(4):771–775CrossRef Loftus TJ, Raymond SL, Sarosi GA Jr, Croft A, Smith RS, Efron PA et al (2017) Predicting appendiceal tumors among patients with appendicitis. J Trauma Acute Care Surg 82(4):771–775CrossRef
23.
go back to reference Smeenk RM, van Velthuysen MLF, Verwaal VJ, Zoetmulder FAN (2008) Appendiceal neoplasms and pseudomyxoma peritonei: a population based study. Eur J Surg Oncol 34(2):196–201CrossRef Smeenk RM, van Velthuysen MLF, Verwaal VJ, Zoetmulder FAN (2008) Appendiceal neoplasms and pseudomyxoma peritonei: a population based study. Eur J Surg Oncol 34(2):196–201CrossRef
24.
go back to reference Kangaspunta H, Tahkola K, Wirta EV, Kotaluoto S, Laukkarinen J, Ukkonen M (2020) Preoperative computed tomography is poor in detecting tumors of the appendix among patients with acute appendicitis: a cohort study of 5,224 appendectomies. J Trauma Acute Care Surg 88(3):396–401CrossRef Kangaspunta H, Tahkola K, Wirta EV, Kotaluoto S, Laukkarinen J, Ukkonen M (2020) Preoperative computed tomography is poor in detecting tumors of the appendix among patients with acute appendicitis: a cohort study of 5,224 appendectomies. J Trauma Acute Care Surg 88(3):396–401CrossRef
25.
go back to reference Oh D, Min Y, Yong J, Jun W (2020) What surgeons should know about emergency operation for COVID-19 confirmed patients: a case report. Int J Surg Case Rep 77:503–506CrossRef Oh D, Min Y, Yong J, Jun W (2020) What surgeons should know about emergency operation for COVID-19 confirmed patients: a case report. Int J Surg Case Rep 77:503–506CrossRef
26.
go back to reference Abdalhadi A, Alkhatib M, Mismar AY, Awouda W, Albarqouni L (2020) Can COVID 19 present like appendicitis? IDCases [Internet] 21:e00860CrossRef Abdalhadi A, Alkhatib M, Mismar AY, Awouda W, Albarqouni L (2020) Can COVID 19 present like appendicitis? IDCases [Internet] 21:e00860CrossRef
27.
go back to reference Alsuwailem AB, Turkistani R, Alomari M (2020) Complicated appendicitis in a pediatric patient with COVID-19: a case report. Cureus 12(6) Alsuwailem AB, Turkistani R, Alomari M (2020) Complicated appendicitis in a pediatric patient with COVID-19: a case report. Cureus 12(6)
28.
go back to reference Moletta L, Pierobon ES, Capovilla G, Costantini M, Salvador R, Merigliano S, Valmasoni M (2020) International guidelines and recommendations for surgery during Covid-19 pandemic: a systematic review. Int J Surg 79:180–188CrossRef Moletta L, Pierobon ES, Capovilla G, Costantini M, Salvador R, Merigliano S, Valmasoni M (2020) International guidelines and recommendations for surgery during Covid-19 pandemic: a systematic review. Int J Surg 79:180–188CrossRef
29.
go back to reference Prante FJ, Bramucci A, Truger A (2020) Decades of tight fiscal policy have left the health care system in Italy ill-prepared to fight the COVID-19 outbreak. Intereconomics. 55(3):147–152CrossRef Prante FJ, Bramucci A, Truger A (2020) Decades of tight fiscal policy have left the health care system in Italy ill-prepared to fight the COVID-19 outbreak. Intereconomics. 55(3):147–152CrossRef
Metadata
Title
Impact of the COVID-19 pandemic on appendicitis treatment in Germany—a population-based analysis
Authors
Franziska Köhler
Laura Acar
Anne van den Berg
Sven Flemming
Carolin Kastner
Sophie Müller
Johannes Diers
Christoph-Thomas Germer
Johann F. Lock
Helmut L’hoest
Ursula Marschall
Armin Wiegering
Publication date
01-03-2021
Publisher
Springer Berlin Heidelberg
Published in
Langenbeck's Archives of Surgery / Issue 2/2021
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI
https://doi.org/10.1007/s00423-021-02081-4

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